Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50021721
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM81393(MPI-0479883)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of N-terminal 6His-tagged human NAMPT expressed in Escherichia coli BL21 (DE3) measured for 1 hr by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM81395(APO-866 | US20240327418, Example FK866 | US2024030...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to NAMPT (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50644013(CHEMBL5591733)
Affinity DataIC50: 23nMAssay Description:Inhibition of NAMPT in human HCT-116 cells assessed as decrease in cellular NAD+ level after 24 hrs by MTT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50435350(CHEMBL17289)
Affinity DataIC50: 25nMAssay Description:Inhibition of Hexahistidine FLAG-tagged human recombinant NAMPT expressed in Escherichia coli BL21(DE3) pLysS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50644008(CHEMBL5440728)
Affinity DataIC50: 41nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM656321(N-(2-Phenyl-1,3-benzoxazol-6-yl)-N′-[(pyridi...)
Affinity DataEC50:  48nMAssay Description:Inhibition of NAMPT (unknown origin) using NAM and PRPP as substrates incubated for 2 hrs in presence of ATP by fluorimetric plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50644009(CHEMBL5570838)
Affinity DataIC50: 80nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50457079(CS-055 | CS055 | Chidamide | Epidaza in China | HB...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50435350(CHEMBL17289)
Affinity DataKd:  120nMAssay Description:Binding affinity to NAMPT (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50644012(CHEMBL5573325)
Affinity DataKi:  200nMAssay Description:Binding affinity to human NAMPT expressed in Escherichia coli BL21 (DE3) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50644015(CHEMBL5595616)
Affinity DataIC50: 279nMAssay Description:Inhibition of NAMPT (unknown origin) using NAM and PRPP as substrates incubated for 2 hrs in presence of ATP by fluorimetric plate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50457079(CS-055 | CS055 | Chidamide | Epidaza in China | HB...)
Affinity DataIC50: 300nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50644011(CHEMBL5575488)
Affinity DataIC50: 400nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50644010(CHEMBL1528242)
Affinity DataIC50: 400nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Mouse)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50644014(CHEMBL5572201)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of N-terminal His-tagged mouse NAMPT transformed in Escherichia coli Rosetta cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50457079(CS-055 | CS055 | Chidamide | Epidaza in China | HB...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed