Compile Data Set for Download or QSAR
Report error Found 71 Enz. Inhib. hit(s) with all data for entry = 50022107
LigandPNGBDBM50608973(CHEMBL4563588)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of his-tagged recombinant human PDE10A catalytic domain extracted from Escherichia coli BL21(DE3) using [3H]-cAMP as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648245(CHEMBL5612110)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648240(CHEMBL6067725)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM31592(PF-2545920 | substituted pyrazole, 9 | US9138494, ...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648233(CHEMBL5613251)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PDE2A (unknown origin) using 3H-cGMP as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648244(CHEMBL5614030)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to PDE9A (unknown origin) using [3H]cAMP as substrate assessed as inhibition constant incubated for 1 hr by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50407426(CHEMBL5271210)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648234(CHEMBL5613718)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PDE2A (unknown origin) using 3H-cGMP as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50407427(CHEMBL5275356)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PDE5A1 (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50458482(CHEMBL4208487)
Affinity DataIC50: 5nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648243(CHEMBL5613182)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648231(CHEMBL5614299)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648237(CHEMBL5613113)
Affinity DataIC50: 8nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50405611(CHEMBL5273419)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of his-tagged recombinant human PDE10A catalytic domain extracted from Escherichia coli BL21(DE3) using [3H]-cAMP as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAcetylcholinesterase(Human)TBA
LigandPNGBDBM50634776(Donepezil | Donepezilo | D-797 | Donaz)
Affinity DataIC50: 10nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50634776(Donepezil | Donepezilo | D-797 | Donaz)
Affinity DataIC50: 11nMAssay Description:Inhibition of PDE5A1 (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50524436(CHEMBL4468513)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant PDE4B1 using FAM-cGMP as substrate preincubated with compound for 15 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50: 11nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50397838(CHEMBL2179105 | US10513524, Reference compound dis...)
Affinity DataIC50: 12nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50634053(CHEMBL5432407)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant PDE11A4 (1 to 943 residues) extracted from Sf9 insect cells using cAMP as substrate pre-incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648229(CHEMBL5612975)
Affinity DataIC50: 14nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50606804(CHEMBL5221005)
Affinity DataIC50: 14nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50606805(CHEMBL5219813)
Affinity DataIC50: 17nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50642264(CHEMBL5571465)
Affinity DataIC50: 21nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50034641(CHEMBL3360415)
Affinity DataIC50: 21nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 27nMAssay Description:Inhibition of PDE3A (unknown origin) using FAM-cAMP as substrate incubated for 45 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50208310(CHEMBL3883753)
Affinity DataIC50: 30nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50408481(CHEMBL5288336)
Affinity DataIC50: 33nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50542296(CHEMBL4641729)
Affinity DataIC50: 36nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648235(CHEMBL5612259)
Affinity DataIC50: 42nMAssay Description:Inhibition of PDE2A (unknown origin) using 3H-cGMP as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648230(CHEMBL5613142)
Affinity DataIC50: 44nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648229(CHEMBL5612975)
Affinity DataIC50: 47nMAssay Description:Inhibition of PDE1C (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant PDE3B using FAM-cyclic-3',5'-AMP as substrate incubated for 1 hrs by fluorescence polarization based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50457396(CHEMBL4206492)
Affinity DataIC50: 52nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648229(CHEMBL5612975)
Affinity DataIC50: 58nMAssay Description:Inhibition of human recombinant GST-tagged PDE1AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50407430(CHEMBL5277578)
Affinity DataIC50: 58nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50458489(CHEMBL4217364)
Affinity DataIC50: 60nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648231(CHEMBL5614299)
Affinity DataIC50: 86nMAssay Description:Inhibition of PDE1C (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50208314(CHEMBL3884788)
Affinity DataIC50: 90nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM70296(PAPAVERINE HYDROCHLORIDE | cid_6084 | 1-[(3,4-dime...)
Affinity DataIC50: 92nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50208310(CHEMBL3883753)
Affinity DataIC50: 95nMAssay Description:Inhibition of human recombinant PDE4B1 using FAM-cGMP as substrate preincubated with compound for 15 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648241(CHEMBL5612243)
Affinity DataIC50: 107nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50591632(CHEMBL5184593)
Affinity DataIC50: 114nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50208314(CHEMBL3884788)
Affinity DataIC50: 144nMAssay Description:Inhibition of human recombinant PDE4B1 using FAM-cGMP as substrate preincubated with compound for 15 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50277784(N,N,2-trimethyl-5-nitrobenzenesulfonamide | CHEMBL...)
Affinity DataIC50: 150nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAcetylcholinesterase(Human)TBA
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 150nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM50591632(CHEMBL5184593)
Affinity DataIC50: 180nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
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