Compile Data Set for Download or QSAR
Report error Found 94 Enz. Inhib. hit(s) with all data for entry = 50022470
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652668(CHEMBL5639978)
Affinity DataIC50: 3nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50249542(6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimid...)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant RET (658 to end residues) expressed in baculovirus Sf21 insect cells by fluorescence polarizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652659(CHEMBL5639321)
Affinity DataIC50: 11nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652659(CHEMBL5639321)
Affinity DataIC50: 11nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652662(CHEMBL5647633)
Affinity DataIC50: 17nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652668(CHEMBL5639978)
Affinity DataIC50: 17nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652670(CHEMBL5639618)
Affinity DataIC50: 21nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652683(CHEMBL5641911)
Affinity DataIC50: 25nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652679(CHEMBL5639989)
Affinity DataIC50: 25nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652672(CHEMBL5647317)
Affinity DataIC50: 28nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50249542(6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimid...)
Affinity DataIC50: 30nMAssay Description:Inhibition of KDR in human HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652669(CHEMBL5639346)
Affinity DataIC50: 31nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652681(CHEMBL5639679)
Affinity DataIC50: 37nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652674(CHEMBL5647091)
Affinity DataIC50: 37nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652657(CHEMBL5639359)
Affinity DataIC50: 39nMAssay Description:Inhibition of Syk in human RBL-2H3 cells assessed as DNP-BSA-induced beta-hexosaminidase secretion preincubated with compound for 20 mins followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652674(CHEMBL5647091)
Affinity DataIC50: 39nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652672(CHEMBL5647317)
Affinity DataIC50: 42nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652659(CHEMBL5639321)
Affinity DataIC50: 42nMAssay Description:Inhibition of Syk in human RBL-2H3 cells assessed as DNP-BSA-induced beta-hexosaminidase secretion preincubated with compound for 20 mins followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652659(CHEMBL5639321)
Affinity DataIC50: 42nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652679(CHEMBL5639989)
Affinity DataIC50: 43nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652681(CHEMBL5639679)
Affinity DataIC50: 46nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652678(CHEMBL5639139)
Affinity DataIC50: 47nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652684(CHEMBL5639470)
Affinity DataIC50: 48nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652667(CHEMBL5639421)
Affinity DataIC50: 50nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652680(CHEMBL5647636)
Affinity DataIC50: 51nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652683(CHEMBL5641911)
Affinity DataIC50: 51nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652678(CHEMBL5639139)
Affinity DataIC50: 51nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652682(CHEMBL5647595)
Affinity DataIC50: 53nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652673(CHEMBL5639659)
Affinity DataIC50: 53nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50249542(6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimid...)
Affinity DataIC50: 54nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652656(CHEMBL5646512)
Affinity DataIC50: 54nMAssay Description:Inhibition of Syk in human RBL-2H3 cells assessed as DNP-BSA-induced beta-hexosaminidase secretion preincubated with compound for 20 mins followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50249542(6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimid...)
Affinity DataIC50: 54nMAssay Description:Inhibition of Syk in human RBL-2H3 cells assessed as DNP-BSA-induced beta-hexosaminidase secretion preincubated with compound for 20 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652680(CHEMBL5647636)
Affinity DataIC50: 55nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652677(CHEMBL5639880)
Affinity DataIC50: 56nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652673(CHEMBL5639659)
Affinity DataIC50: 60nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652668(CHEMBL5639978)
Affinity DataIC50: 61nMAssay Description:Inhibition of his-tagged human recombinant KDR incubated for 60 mins by Z'lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652658(CHEMBL5639650)
Affinity DataIC50: 62nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652675(CHEMBL5647671)
Affinity DataIC50: 66nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652670(CHEMBL5639618)
Affinity DataIC50: 68nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652684(CHEMBL5639470)
Affinity DataIC50: 68nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652660(CHEMBL5639533)
Affinity DataIC50: 72nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652671(CHEMBL5639775)
Affinity DataIC50: 73nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652682(CHEMBL5647595)
Affinity DataIC50: 75nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652677(CHEMBL5639880)
Affinity DataIC50: 90nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652676(CHEMBL5647165)
Affinity DataIC50: 90nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652659(CHEMBL5639321)
Affinity DataIC50: 97nMAssay Description:Inhibition of his-tagged human recombinant KDR incubated for 60 mins by Z'lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652662(CHEMBL5647633)
Affinity DataIC50: 100nMAssay Description:Inhibition of Syk in human RBL-2H3 cells assessed as DNP-BSA-induced beta-hexosaminidase secretion preincubated with compound for 20 mins followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652663(CHEMBL5639485)
Affinity DataIC50: 105nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652656(CHEMBL5646512)
Affinity DataIC50: 109nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652660(CHEMBL5639533)
Affinity DataIC50: 109nMAssay Description:Inhibition of Syk in human RBL-2H3 cells assessed as DNP-BSA-induced beta-hexosaminidase secretion preincubated with compound for 20 mins followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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