Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50021943
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50582889(CHEMBL5073608)
Affinity DataIC50: 7nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50582885(CHEMBL5091591)
Affinity DataIC50: 8nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50582894(CHEMBL5076615)
Affinity DataIC50: 10nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50594406(EZM-0414 | Ezm-0414 | EZM0414)
Affinity DataIC50: 18nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50627890(CHEMBL5422577)
Affinity DataKd:  24nMAssay Description:Binding affinity to NSD2 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Binding affinity to NSD2 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 110nMAssay Description:Inhibition of NSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50572787(CHEMBL4860876)
Affinity DataIC50: 132nMAssay Description:Inhibition of NSD2 SET domain (unknown origin) extracted from Escherichia coli BL21More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608082(CHEMBL5265919)
Affinity DataIC50: 203nMAssay Description:Inhibition of GST-tagged NSD3 (247 to 398 residues) (unknown origin) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataKd:  445nMAssay Description:Binding affinity to human NSD3 PWWP1 domain (247 to 398 residues) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50646359(CHEMBL5077328)
Affinity DataIC50: 600nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 incubated for 60 mins by ITC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50582901(CHEMBL5085128)
Affinity DataIC50: 600nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50646360(CHEMBL5085204)
Affinity DataIC50: 790nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 incubated for 60 mins by ITC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598857(CHEMBL5195436)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to NSD2 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50627888(CHEMBL5413676)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to NSD3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50646355(CHEMBL5595246)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50582886(CHEMBL5085724)
Affinity DataIC50: 3.08E+3nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50075101(CHEMBL3414624)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50646354(CHEMBL5592110)
Affinity DataIC50: 4.24E+3nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608077(CHEMBL5270736)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of NSD1 (unknown origin) methyltransferase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMyc proto-oncogene protein(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human c-Myc in human MOLM-13 cells assessed as decrease in c-Myc protein expression level incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608077(CHEMBL5270736)
Affinity DataIC50: 1.43E+4nMAssay Description:Inhibition of NSD3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50646357(CHEMBL4551717)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 incubated for 60 mins by ITC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM378212(N-((1r,4r)-4-(3-aminopropanamido)cyclohexyl)-7-met...)
Affinity DataIC50: 2.21E+4nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50646358(CHEMBL4556344)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 incubated for 60 mins by ITC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608077(CHEMBL5270736)
Affinity DataIC50: 2.67E+4nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50646356(CHEMBL4580008)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 incubated for 60 mins by ITC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608076(CHEMBL5281547)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of NSD1 (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608082(CHEMBL5265919)
Affinity DataKd:  1.60E+5nMAssay Description:Binding affinity to human NSD3 PWWP1 domain (247 to 398 residues) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50646353(CHEMBL5592690)
Affinity DataIC50: 1.66E+5nMAssay Description:Inhibition of MMSET (953 to 1240 residues) (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50555100(CHEMBL4749457)
Affinity DataKd:  3.30E+5nMAssay Description:Binding affinity to human NSD3 PWWP1 domain (247 to 398 residues) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608081(CHEMBL5270364)
Affinity DataKd:  6.50E+5nMAssay Description:Binding affinity to human NSD3 PWWP1 domain (247 to 398 residues) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)