Compile Data Set for Download or QSAR
Report error Found 78 Enz. Inhib. hit(s) with all data for entry = 50022028
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to METTL3/METTL14 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to METTL3 (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621556(CHEMBL5396973)
Affinity DataIC50: 5nMAssay Description:Inhibition of METTL3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621554(CHEMBL5405105)
Affinity DataIC50: 5nMAssay Description:Inhibition of full length His-tagged METTL3 co-expressed with full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression sy...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621556(CHEMBL5396973)
Affinity DataIC50: 5nMAssay Description:Inhibition of full length His-tagged METTL3 co-expressed with full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression sy...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621554(CHEMBL5405105)
Affinity DataIC50: 5nMAssay Description:Inhibition of METTL3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetYTH domain-containing protein 1(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50647357(CHEMBL5598203)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of YTHDC1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621552(CHEMBL5402970)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of METTL3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621552(CHEMBL5402970)
Affinity DataIC50: 8nMAssay Description:Inhibition of full length His-tagged METTL3 co-expressed with full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression sy...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621567(CHEMBL5081437)
Affinity DataIC50: 10nMAssay Description:Inhibition of full-length human recombinant METTL3 (369 to 580 residues) expressed in baculovirus expression system infected in Sf9 cells by fluoresc...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621575(CHEMBL5081947)
Affinity DataIC50: 10nMAssay Description:Inhibition of METTL3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621567(CHEMBL5081437)
Affinity DataIC50: 10nMAssay Description:Inhibition of METTL3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621575(CHEMBL5081947)
Affinity DataIC50: 10nMAssay Description:Inhibition of full-length human recombinant METTL3 (369 to 580 residues) expressed in baculovirus expression system infected in Sf9 cells by fluoresc...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length His-tagged METTL3 (unknown origin) expressed in Sf9 cells by RapidFire mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length His-tagged METTL3 co-expressed with full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621554(CHEMBL5405105)
Affinity DataIC50: 25nMAssay Description:Inhibition of METTL3/METTL14 (unknown origin) by RapidFire mass spectrometry analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetYTH domain-containing protein 1(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50647357(CHEMBL5598203)
Affinity DataKd:  30nMAssay Description:Binding affinity to YTHDC1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM589235(US11555009, Compound 15 | US11555009, Compound 29)
Affinity DataIC50: 60nMAssay Description:Inhibition of N-terminal FTO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRNA demethylase ALKBH5(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50060768(9,10-anthracenedicarboxaldehyde Bis[(4,5-dihydro-1...)
Affinity DataIC50: 140nMAssay Description:Inhibition of ALKBH5 (66 to 292 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) using 5'-ATTGTCA(m6A)CAGCAGA-FAM-3' as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611058(CHEMBL5279050)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant METTL3/METTL14 (unknown origin) expressed in baculovirus infected in Sf9 cells by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM589244(US11555009, Compound 32)
Affinity DataIC50: 400nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-rib...)
Affinity DataIC50: 520nMAssay Description:Inhibition of METTL3/METTL14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50647347(CHEMBL1253979)
Affinity DataIC50: 640nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRNA demethylase ALKBH5(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...)
Affinity DataIC50: 710nMAssay Description:Inhibition of ALKBH5 (66 to 292 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) using 5'-ATTGTCA(m6A)CAGCAGA-FAM-3' as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50647348(CHEMBL5597797)
Affinity DataIC50: 780nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRNA demethylase ALKBH5(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50557836(CHEMBL4752151)
Affinity DataIC50: 840nMAssay Description:Inhibition of N-terminal ALKBH5 (unknown origin) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621575(CHEMBL5081947)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of METTL3 in human MOLM-13 cells assessed as down regulation of m6A RNA level incubated for 72 hrs by Dot blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621567(CHEMBL5081437)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of METTL3 in human MOLM-13 cells assessed as down regulation of m6A RNA level incubated for 72 hrs by Dot blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of METTL3/METTL14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50647346(CHEMBL5597856)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611053(CHEMBL5281651)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of FTO (unknown origin) expressed in Escherichia coli BL21(DE3) using 5'-TAGACATTGCCATTCTCGATAGG(m6A)-TCCGGTCAAACCTAGACGAATTCCA-3' as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM32018(cid_26248 | SMR000058958 | MLS000028577 | 4,5-diac...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of FTO (unknown origin) expressed in Escherichia coli BL21(DE3) using 5'-TAGACATTGCCATTCTCGATAGG(m6A)-TCCGGTCAAACCTAGACGAATTCCA-3' as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRNA demethylase ALKBH5(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50647354(CHEMBL5597347)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of ALKBH5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of human METTL3 expressed in HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetYTH domain-containing protein 1(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50129950(EBSELEN)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of YTHDC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetYTH domain-containing protein 1(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50601383(CHEMBL5177286)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to YTHDC1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRNA demethylase ALKBH5(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50557837(CHEMBL4753950)
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of N-terminal ALKBH5 (unknown origin) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM624850(US20230322715, Compound FTO-2)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of FTO (unknown origin) expressed in Escherichia coli by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of METTL3 in human MOLM-13 cells assessed as down regulation of m6A RNA level incubated for 72 hrs by Dot blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM589237(US11555009, Compound 25)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of N-terminal FTO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of full length His-tagged METTL3 co-expressed with full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50193145(Isoquinoline 3 | CHEMBL426560 | N-[(1-CHLORO-4-HYD...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of FTO (unknown origin) expressed in Escherichia coli BL21(DE3) using 5'-TAGACATTGCCATTCTCGATAGG(m6A)-TCCGGTCAAACCTAGACGAATTCCA-3' as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621559(CHEMBL5426510)
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of full-length human recombinant METTL3 (369 to 580 residues) expressed in baculovirus expression system infected in Sf9 cells by fluoresc...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN(6)-adenosine-methyltransferase catalytic subunit METTL3(Mus musculus)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of mouse METTL3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of FTO (unknown origin) expressed in Escherichia coli BL21(DE3) using 5'-TAGACATTGCCATTCTCGATAGG(m6A)-TCCGGTCAAACCTAGACGAATTCCA-3' as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50647349(CHEMBL5597712)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of FTO (unknown origin) expressed in Escherichia coli by FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of FTO (unknown origin) expressed in Escherichia coli BL21(DE3) using 5'-TAGACATTGCCATTCTCGATAGG(m6A)-TCCGGTCAAACCTAGACGAATTCCA-3' as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetYTH domain-containing family protein 1(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50129950(EBSELEN)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of YTHDF1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621559(CHEMBL5426510)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of METTL3 in human Huh-7 cells assessed as down regulation of m6A RNA level at 2 uM incubated for 72 hrs by colorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621559(CHEMBL5426510)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of METTL3 in human MOLM-13 cells assessed as down regulation of m6A RNA level incubated for 72 hrs by Dot blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Displayed 1 to 50 (of 78 total ) | Next | Last >>
Jump to: