Compile Data Set for Download or QSAR
Report error Found 270 Enz. Inhib. hit(s) with all data for entry = 50020984
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM315715(US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM315715(US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human PI3Kdelta using PI(4,5)P2:PS as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PI3Kalpha using PI(4,5)P2:PS as substrate in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635810(CHEMBL5559388)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM413450(US10407446, Example 3 | 7-methyl-2-((7-methyl-[1,2...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human mTOR in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635809(CHEMBL5527881)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635808(CHEMBL5559285)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM315715(US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human PI3Kbeta using PI(4,5)P2:PS as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635806(CHEMBL5517961)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635805(CHEMBL5532026)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635799(CHEMBL5556014)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635807(CHEMBL5558866)
Affinity DataIC50: 7nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635802(CHEMBL5542587)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635778(CHEMBL5555639)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM315715(US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human PI3Kalpha using PI(4,5)P2:PS as substrate in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635772(CHEMBL5555573)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635800(CHEMBL5542350)
Affinity DataIC50: 8nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635769(CHEMBL5512590)
Affinity DataIC50: 18nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635779(CHEMBL5542711)
Affinity DataIC50: 22nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635781(CHEMBL5557396)
Affinity DataIC50: 30nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635804(CHEMBL5558337)
Affinity DataIC50: 32nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635770(CHEMBL5527866)
Affinity DataIC50: 40nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635816(CHEMBL5531947)
Affinity DataIC50: 40nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635803(CHEMBL5559345)
Affinity DataIC50: 40nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635811(CHEMBL5517925)
Affinity DataIC50: 43nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635815(CHEMBL5542141)
Affinity DataIC50: 53nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635765(CHEMBL5532291)
Affinity DataIC50: 63nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635782(CHEMBL5523377)
Affinity DataIC50: 73nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635776(CHEMBL5549794)
Affinity DataIC50: 73nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635773(CHEMBL5559046)
Affinity DataIC50: 75nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635812(CHEMBL5543038)
Affinity DataIC50: 77nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635788(CHEMBL5559461)
Affinity DataIC50: 94nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635791(CHEMBL5557807)
Affinity DataIC50: 97nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635818(CHEMBL6067692)
Affinity DataIC50: 100nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635783(CHEMBL5523471)
Affinity DataIC50: 100nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635796(CHEMBL5559203)
Affinity DataIC50: 108nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635811(CHEMBL5517925)
Affinity DataIC50: 123nMAssay Description:Inhibition of human PI3Kalpha using PI(4,5)P2:PS as substrate in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635771(CHEMBL5523582)
Affinity DataIC50: 137nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635797(CHEMBL5542179)
Affinity DataIC50: 138nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635793(CHEMBL5556556)
Affinity DataIC50: 138nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635801(CHEMBL5532012)
Affinity DataIC50: 140nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635792(CHEMBL5542181)
Affinity DataIC50: 147nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635813(CHEMBL5532346)
Affinity DataIC50: 150nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635817(CHEMBL5523472)
Affinity DataIC50: 157nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635731(CHEMBL5559035)
Affinity DataIC50: 185nMAssay Description:Inhibition of human DNA-PK using EPPLSQEAFADLWK as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50635813(CHEMBL5532346)
Affinity DataIC50: 187nMAssay Description:Inhibition of human PI3Kalpha using PI(4,5)P2:PS as substrate in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50635775(CHEMBL5523360)
Affinity DataIC50: 193nMAssay Description:Inhibition of human JNK2 using 33P as substrate in presence of ATP by kinase hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
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