Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50021399
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640212(CHEMBL5566068)
Affinity DataKd:  0.0960nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 assessed as dissociation constant at 2 uM by Grating-Coupled InterferometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640214(Vociprotafib | Ptpn11 inhibitor rmc-4630 | Rmc 463...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of wild type SHP2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM384117(US10280171, Example 1 | 1-(3-(2,3-dichlorophenyl)-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal 6His tagged wild type human SHP2 (1 to 530 residues) using DiFMUP as substrate preincubated for 30 mins in presence of bisph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640216(Pf-07284892 | ARRY-558)
Affinity DataIC50: 21nMAssay Description:Inhibition of C-terminal 6His-tagged full length SHP2 (2 to 527 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640215(Jab 3068 | Jab-3068 | JAB3068)
Affinity DataIC50: 26nMAssay Description:Inhibition of wild type SHP2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM395995(US10308660, Example 96)
Affinity DataIC50: 31nMAssay Description:Inhibition of wild type SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50546224(CHEMBL4746963 | US11739093, Compound 2 | US2024019...)
Affinity DataIC50: 34nMAssay Description:Inhibition of wild type SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50587735(CHEMBL5182949)
Affinity DataIC50: 71nMAssay Description:Inhibition of wild type human SHP2 catalytic domain (248 to 527 residues) using DiFMUP as substrate preincubated for 1 hr followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataIC50: 210nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640212(CHEMBL5566068)
Affinity DataKd:  290nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 assessed as equilibrium dissociation constant at 2 uM by Grating-Coupled Inter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640212(CHEMBL5566068)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640213(CHEMBL5567483)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50404040(CHEMBL5288934)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of wild type SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640203(CHEMBL5561430)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640210(CHEMBL5562224)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640207(CHEMBL5560951)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640208(CHEMBL5560734)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640206(CHEMBL5564344)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640209(CHEMBL5559291)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640204(CHEMBL5563722)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640205(CHEMBL5565075)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50640211(CHEMBL5559607)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of full length 6His-tagged wild type recombinant human SHP2 transfected in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed