Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50022197
TargetCarbonic anhydrase 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649327(CHEMBL5619229)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human carbonic anhydrase IMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649328(CHEMBL5618562)
Affinity DataIC50: 12nMAssay Description:Inhibition of human carbonic anhydrase IMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50592604(CHEMBL5201264)
Affinity DataIC50: 13nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649328(CHEMBL5618562)
Affinity DataIC50: 17nMAssay Description:Inhibition of human carbonic anhydrase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649327(CHEMBL5619229)
Affinity DataIC50: 21nMAssay Description:Inhibition of human carbonic anhydrase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50515315(CHEMBL4527908)
Affinity DataIC50: 30nMAssay Description:Inhibition of ALK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50540056(CHEMBL4638983)
Affinity DataIC50: 30nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649325(CHEMBL5618216)
Affinity DataIC50: 90nMAssay Description:Inhibition of C-terminal His-tagged SIRT2 (50 to 356 residues) (unknown origin) using Ac-Glu-Thr-Asp-Lys(Myr)-AMC as substrate by fluorescence based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649326(CHEMBL5618570)
Affinity DataIC50: 100nMAssay Description:Inhibition of C-terminal His-tagged SIRT2 (50 to 356 residues) (unknown origin) using Ac-Glu-Thr-Asp-Lys(Myr)-AMC as substrate by fluorescence based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50515313(CHEMBL4570292)
Affinity DataIC50: 125nMAssay Description:Inhibition of ALK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649323(CHEMBL5619849)
Affinity DataIC50: 340nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50646359(CHEMBL5077328)
Affinity DataIC50: 600nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50646360(CHEMBL5085204)
Affinity DataIC50: 790nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM195606(NCT-503)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human PHGDH extracted from Escherichia coli Rossetta 2 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM195605(NCT-502 | US11225469, Compound 72)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of PHGDH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649321(CHEMBL4546073)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50230347(CHEMBL4096521)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of PHGDH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM34554((4-chlorophenyl)-morpholin-4-yl-methanethione | (4...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of PHGDH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50646357(CHEMBL4551717)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM429242(jm5b01461, Compound 59 | acs.jmedchem.1c00409_ST.4)
Affinity DataKi:  1.76E+4nMAssay Description:Binding affinity to SARS-CoV-2 MPro assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50646358(CHEMBL4556344)
Affinity DataIC50: 2.35E+4nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50646356(CHEMBL4580008)
Affinity DataIC50: 5.05E+4nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649322(CHEMBL5619490)
Affinity DataIC50: 7.20E+4nMAssay Description:Inhibition of N-terminal ASH1L SET domain (2069 to 2288) (unknown origin) extracted from Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50540056(CHEMBL4638983)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of SIRT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649324(CHEMBL5620054)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50540056(CHEMBL4638983)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649324(CHEMBL5620054)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50540056(CHEMBL4638983)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649324(CHEMBL5620054)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50649324(CHEMBL5620054)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed