Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50022072
LigandPNGBDBM50592747(CHEMBL5195904)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of EGFR Del19/T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50581524(CHEMBL5078405)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50647813(CHEMBL5597724)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of EGFR Del19/T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50581523(CHEMBL5092943)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50581522(CHEMBL5075273)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50581522(CHEMBL5075273)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of wild type TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM561454(US11390625, Compound 34 | US11390625, Example 34)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50581524(CHEMBL5078405)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition o wild type TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50581524(CHEMBL5078405)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild type TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition o wild type TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50647810(Zotizalkib | Tpx 0131 | Tpx-0131 | TPX-0131 | TPX0...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50647811(Zidesamtinib | Nvl-520 | NU-0002362 | NU-0002362-0...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of wild type ROS1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50581523(CHEMBL5092943)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50546200(Vecabrutinib | Sns-062 | BIIB-062 | BSK-4841 | FP-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50647810(Zotizalkib | Tpx 0131 | Tpx-0131 | TPX-0131 | TPX0...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50647812(Ff-10101 | FLT3-IN-1)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using MBP as substrate incubated for 2 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM144333(US8969336, 577 | US12350272, Compound ASP2215)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using MBP as substrate incubated for 2 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 2nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM537926(US11248003, Example 1)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of TRKC (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50647814(CHEMBL5591124)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of EGFR Del19/T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50647809(CHEMBL5596270)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50647812(Ff-10101 | FLT3-IN-1)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50468192(CHEMBL4294743)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50468192(CHEMBL4294743)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50581522(CHEMBL5075273)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50581523(CHEMBL5092943)
Affinity DataIC50: 14nMAssay Description:Inhibition of wild type TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM537979(US11248003, Example TRE-069)
Affinity DataIC50: 15nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50546200(Vecabrutinib | Sns-062 | BIIB-062 | BSK-4841 | FP-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of RET G810R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50500356(CHEMBL3747406 | US11066363, Compound 7)
Affinity DataIC50: 22nMAssay Description:Inhibition of EML4-ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50647812(Ff-10101 | FLT3-IN-1)
Affinity DataIC50: 22nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50468244(CHEMBL4284413)
Affinity DataIC50: 24nMAssay Description:Inhibition of EGFR Del19/T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50518964(CHEMBL4474196)
Affinity DataIC50: 28nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM144333(US8969336, 577 | US12350272, Compound ASP2215)
Affinity DataIC50: 32nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 38nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 48nMAssay Description:Inhibition of TRKC G623R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50500356(CHEMBL3747406 | US11066363, Compound 7)
Affinity DataIC50: 61nMAssay Description:Inhibition of EML4-ALK (unknown origin) expressed in mouse BaF3 cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 80nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM144333(US8969336, 577 | US12350272, Compound ASP2215)
Affinity DataIC50: 117nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 381nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50518964(CHEMBL4474196)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed