Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 50023458
TargetProtein arginine N-methyltransferase 5(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663904BDBM50663904(CHEMBL4872234)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity to PRMT5 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 694787BDBM694787(US20240294545, Compound A-33)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663898BDBM50663898(CHEMBL6171509)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 694769BDBM694769(US20240294545, Compound A-22)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 438104BDBM438104(US10597399, Compound S36)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 694765BDBM694765(US20240294545, Compound A-193)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565800BDBM50565800(Azd-1390 | Azd1390 | US20240294545, Compound AZD13...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetWee1-like protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635712BDBM50635712(CHEMBL5555318)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of WEE1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594871BDBM50594871(CHEMBL5173530)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant ATR incubated for 40 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 724380BDBM724380(US20250066350, Example RP3500)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant ATR incubated for 40 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetWee1-like protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240826BDBM50240826(AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of WEE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase ATR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594873BDBM50594873(CHEMBL5171719)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant ATR incubated for 40 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 620109BDBM620109((R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-7-(1H...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant ATR incubated for 40 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663899BDBM50663899(CHEMBL6167720)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50645130BDBM50645130(CHEMBL5566839)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663902BDBM50663902(CHEMBL6143539)
Affinity DataIC50: 12nMAssay Description:Inhibition of WRN (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663897BDBM50663897(CHEMBL6170410)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant ATR incubated for 40 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50626785BDBM50626785(CHEMBL5396891)
Affinity DataIC50: 23nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663895BDBM50663895(CHEMBL5565971)
Affinity DataIC50: 23nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663896BDBM50663896(CHEMBL6173667)
Affinity DataIC50: 26nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50650930BDBM50650930(CHEMBL5633539)
Affinity DataIC50: 30nMAssay Description:Inhibition of human PARP2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50650930BDBM50650930(CHEMBL5633539)
Affinity DataIC50: 34nMAssay Description:Inhibition of human PARP1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50645132BDBM50645132(CHEMBL5570496)
Affinity DataIC50: 43nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCyclin-dependent kinase 13(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528813BDBM50528813(CHEMBL4163879 | US20250101023, Example THZ531)
Affinity DataIC50: 69nMAssay Description:Inhibition of human CDK13 by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase VRK1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663903BDBM50663903(CHEMBL6170056)
Affinity DataIC50: 112nMAssay Description:Inhibition of VRK1 (3 to 364 residues) (unknown origin) extracted from Escherichia coli BL21 (DE3)-R3 cellsMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 724380BDBM724380(US20250066350, Example RP3500)
Affinity DataIC50: 120nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528813BDBM50528813(CHEMBL4163879 | US20250101023, Example THZ531)
Affinity DataIC50: 158nMAssay Description:Inhibition of human CDK12 by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase VRK2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663903BDBM50663903(CHEMBL6170056)
Affinity DataIC50: 196nMAssay Description:Inhibition of VRK2 (14 to 335 residues) (unknown origin) extracted from Escherichia coli BL21 (DE3)-R3 cellsMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 13(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110178BDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50: 225nMAssay Description:Inhibition of human CDK13 by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50651691BDBM50651691(CHEMBL1968672)
Affinity DataIC50: 230nMAssay Description:Inhibition of WRN (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50650930BDBM50650930(CHEMBL5633539)
Affinity DataIC50: 285nMAssay Description:Inhibition of human CDK12More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25120BDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 480nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663896BDBM50663896(CHEMBL6173667)
Affinity DataIC50: 620nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetDNA repair protein RAD51 homolog 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663901BDBM50663901(CHEMBL6175342)
Affinity DataIC50: 720nMAssay Description:Inhibition of RAD51 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110178BDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50: 864nMAssay Description:Inhibition of human CDK12 by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594869BDBM50594869(CHEMBL5178144)
Affinity DataIC50: 938nMAssay Description:Inhibition of human recombinant ATR incubated for 40 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetDNA repair protein RAD51 homolog 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663901BDBM50663901(CHEMBL6175342)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to RAD51 (unknown origin) assessed as dissociation constant by SRP assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50524326BDBM50524326(CHEMBL4538448)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50651692BDBM50651692(CHEMBL1399711)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of WRN (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetDNA repair protein RAD51 homolog 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663900BDBM50663900(CHEMBL6168507)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of RAD51 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetRecQ-like DNA helicase BLM(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50440531BDBM50440531(CHEMBL2426168)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of BLM (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50440531BDBM50440531(CHEMBL2426168)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of WRN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetRecQ-like DNA helicase BLM(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50651692BDBM50651692(CHEMBL1399711)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of BLM (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50651693BDBM50651693(CHEMBL1353989)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of WRN (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetDNA repair protein RAD51 homolog 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 48804BDBM48804(MLS000709026 | 3-(phenylmethyl)-2-[(E)-2-pyridin-3...)
Affinity DataKd:  1.46E+4nMAssay Description:Binding affinity to RAD51 (unknown origin) assessed as dissociation constant by SRP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetDNA repair protein RAD51 homolog 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663900BDBM50663900(CHEMBL6168507)
Affinity DataKd:  1.46E+4nMAssay Description:Binding affinity to RAD51 (unknown origin) assessed as dissociation constant by SRP assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetDNA repair protein RAD51 homolog 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 48804BDBM48804(MLS000709026 | 3-(phenylmethyl)-2-[(E)-2-pyridin-3...)
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of RAD51 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044626BDBM50044626(CHEMBL1374426)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of WRN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetRecQ-like DNA helicase BLM(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50651693BDBM50651693(CHEMBL1353989)
Affinity DataIC50: 4.61E+4nMAssay Description:Inhibition of BLM (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed