Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50022156
Affinity DataIC50: 3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Human)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant MAO-B using para-tyramine as substrate by Amplex Red fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Human)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant MAO-B using para-tyramine as substrate by Amplex Red fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GDT tagged human NCOR2 (395 to 489 residues) extracted fro...More data for this Ligand-Target Pair
Affinity DataIC50: 87nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 99nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 135nMAssay Description:Inhibition of C-terminal FLAG-tagged full length human recombinant HDAC2 (1 to 488 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 137nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 168nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 243nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 295nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Human)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataIC50: 384nMAssay Description:Inhibition of human recombinant MAO-B using para-tyramine as substrate by Amplex Red fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 735nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataIC50: 937nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GDT tagged human NCOR2 (395 to 489 residues) extracted fro...More data for this Ligand-Target Pair
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.92E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged full length human recombinant HDAC2 (1 to 488 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataIC50: 2.53E+3nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GDT tagged human NCOR2 (395 to 489 residues) extracted fro...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GDT tagged human NCOR2 (395 to 489 residues) extracted fro...More data for this Ligand-Target Pair
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 3.33E+3nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Human)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataKi: 3.39E+3nMAssay Description:Displacement of [3H]-LSD from human 5-HT6 receptor extracted from CHO-K1 cell membrane assessed as inhibition constant incubated for 1 hr by Microbet...More data for this Ligand-Target Pair
Affinity DataIC50: 3.39E+3nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 3.99E+3nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of C-terminal 6His/FLAG tagged full length human recombinant HDAC1 (1 to 482 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 4.16E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged full length human recombinant HDAC2 (1 to 488 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Human)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataKi: 4.31E+3nMAssay Description:Displacement of [3H]-LSD from human 5-HT6 receptor extracted from CHO-K1 cell membrane assessed as inhibition constant incubated for 1 hr by Microbet...More data for this Ligand-Target Pair
Affinity DataIC50: 5.41E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged full length human recombinant HDAC2 (1 to 488 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Human)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataKi: 5.82E+3nMAssay Description:Displacement of [3H]-LSD from human 5-HT6 receptor extracted from CHO-K1 cell membrane assessed as inhibition constant incubated for 1 hr by Microbet...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Human)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataKi: 6.38E+3nMAssay Description:Displacement of [3H]-LSD from human 5-HT6 receptor extracted from CHO-K1 cell membrane assessed as inhibition constant incubated for 1 hr by Microbet...More data for this Ligand-Target Pair
Affinity DataIC50: 8.81E+3nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Institute of General Organic Chemistry (CSIC)
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GDT tagged human NCOR2 (395 to 489 residues) extracted fro...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair

3D Structure (crystal)


















