Compile Data Set for Download or QSAR
Report error Found 52 Enz. Inhib. hit(s) with all data for entry = 50022170
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50648950(CHEMBL5613744)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of human PRMT5/MEP50 using Histone H2 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PRMT4 using histone H3 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648947(CHEMBL5613749)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human PRMT4 using histone H3 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50597884(CHEMBL5185202)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PRMT7 (unknown origin) incubated for 1 hr in presence of 3H-SAM by topcount plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648950(CHEMBL5613744)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human PRMT4 using histone H3 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648951(CHEMBL5613785)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648948(CHEMBL5613986)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of human PRMT4 using histone H3 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648951(CHEMBL5613785)
Affinity DataIC50: 16nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648951(CHEMBL5613785)
Affinity DataIC50: 18nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648952(CHEMBL5612816)
Affinity DataIC50: 23nMAssay Description:Inhibition of PRMT4 in human MDA-MB-231 cells assessed as decrease in PABP1 methylation level incubated for 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648952(CHEMBL5612816)
Affinity DataIC50: 31nMAssay Description:Inhibition of PRMT4 in human MDA-MB-231 cells assessed as decrease in PABP1 methylation level incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648951(CHEMBL5613785)
Affinity DataIC50: 31nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648951(CHEMBL5613785)
Affinity DataIC50: 32nMAssay Description:Inhibition of PRMT8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648952(CHEMBL5612816)
Affinity DataIC50: 42nMAssay Description:Inhibition of PRMT4 in human MDA-MB-231 cells assessed as decrease in BAF155 methylation level incubated for 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648949(CHEMBL5612781)
Affinity DataIC50: 49nMAssay Description:Inhibition of human PRMT4 using histone H3 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 73nMAssay Description:Inhibition of PRMT4 in human MDA-MB-231 cells assessed as decrease in BAF155 methylation level incubated for 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648945(CHEMBL5613745)
Affinity DataIC50: 138nMAssay Description:Inhibition of human PRMT4 using histone H3 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50597884(CHEMBL5185202)
Affinity DataIC50: 140nMAssay Description:Inhibition of PRMT4 (unknown origin) incubated for 1 hr in presence of 3H-SAM by topcount plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50597884(CHEMBL5185202)
Affinity DataIC50: 150nMAssay Description:Inhibition of PRMT5/MEP50 (unknown origin) incubated for 1 hr in presence of 3H-SAM by topcount plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 181nMAssay Description:Inhibition of PRMT4 in human MDA-MB-231 cells assessed as decrease in BAF155 methylation level incubated for 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataKd:  188nMAssay Description:Binding affinity to PRMT4 (140 to 480 residues) (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648945(CHEMBL5613745)
Affinity DataIC50: 321nMAssay Description:Inhibition of human PRMT3 using Histone H3 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648951(CHEMBL5613785)
Affinity DataIC50: 321nMAssay Description:Inhibition of PRMT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648952(CHEMBL5612816)
Affinity DataIC50: 343nMAssay Description:Inhibition of PRMT4 in human MDA-MB-231 cells assessed as decrease in BAF155 methylation level incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648945(CHEMBL5613745)
Affinity DataIC50: 351nMAssay Description:Inhibition of human PRMT5/MEP50 using Histone H2 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648951(CHEMBL5613785)
Affinity DataIC50: 555nMAssay Description:Inhibition of PRMT7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50597884(CHEMBL5185202)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of PRMT1 (unknown origin) incubated for 1 hr in presence of 3H-SAM by topcount plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50597884(CHEMBL5185202)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of PRMT6 (unknown origin) incubated for 1 hr in presence of 3H-SAM by topcount plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50597884(CHEMBL5185202)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) incubated for 1 hr in presence of 3H-SAM by topcount plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648945(CHEMBL5613745)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human PRMT7 using GST-GAR as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648950(CHEMBL5613744)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human PRMT1 using Histone H4 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50597884(CHEMBL5185202)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of PRMT8 (unknown origin) incubated for 1 hr in presence of 3H-SAM by topcount plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648950(CHEMBL5613744)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of human PRMT7 using GST-GAR as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NSD2 using nucleosomes as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648950(CHEMBL5613744)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PRMT3 using Histone H3 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648945(CHEMBL5613745)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648950(CHEMBL5613744)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PRMT8 using Histone H4 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648945(CHEMBL5613745)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PRMT8 using Histone H4 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648945(CHEMBL5613745)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PRMT1 using Histone H4 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human PRMT7 using GST-GAR as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human PRMT5/MEP50 using Histone H2 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human PRMT3 using Histone H3 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
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