Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50022750
TargetNeprilysin(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073120BDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataKi:  0.450nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNeprilysin(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50067033BDBM50067033(2,6-Bis-[1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-y...)
Affinity DataKi:  0.640nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetNeprilysin(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50646594BDBM50646594(Dl-thiorphan | Thiorphan | NSC-727676)
Affinity DataKi:  4nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetNeprilysin(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073120BDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNeprilysin(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50281657BDBM50281657(cis-4-[({1-[(2S)-2-carboxy-3-(2-methoxyethoxy)prop...)
Affinity DataKi:  6.10nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetNeprilysin(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653882BDBM50653882(CHEMBL6162201)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetNeprilysin(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653883BDBM50653883(CHEMBL1794668)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653884BDBM50653884(CHEMBL6148868)
Affinity DataKi:  120nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetNeprilysin(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653881BDBM50653881(CHEMBL6148579)
Affinity DataIC50: 1.70E+3nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetType-2 angiotensin II receptor(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50103763BDBM50103763(CHEBI:11684 | Reverse Tri-Iodothyronine | REVERSE ...)
Affinity DataIC50: 2.98E+4nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed