Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50022667
TargetDNA-binding protein Ikaros/Protein cereblon(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476157BDBM50476157(CHEMBL6074489)
Affinity DataEC50:  35nMAssay Description:Inhibition of TRKA (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292750BDBM292750(US20260014133, Compound 11)
Affinity DataEC50:  64nMAssay Description:Inhibition of AURKA (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292772BDBM292772(US20260014133, Compound 33)
Affinity DataEC50:  72nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292742BDBM292742(US20260014133, Compound 3)
Affinity DataEC50:  100nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292740BDBM292740(US20260014133, Compound 1)
Affinity DataEC50:  105nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292747BDBM292747(US20260014133, Compound 8)
Affinity DataEC50:  119nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetDNA-binding protein Ikaros/Protein cereblon(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 730416BDBM730416(US20250122166, Compound 7)
Affinity DataEC50:  120nMAssay Description:Inhibition of TIE2 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292743BDBM292743(US20260014133, Compound 4)
Affinity DataEC50:  127nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292751BDBM292751(US20260014133, Compound 12)
Affinity DataEC50:  129nMAssay Description:Positive allosteric modulation of rat mGlu5 assessed as calcium mobilization by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476158BDBM50476158(CHEMBL6133892)
Affinity DataEC50:  137nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292744BDBM292744(US20260014133, Compound 5)
Affinity DataEC50:  178nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476159BDBM50476159(CHEMBL6101959)
Affinity DataEC50:  202nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 730416BDBM730416(US20250122166, Compound 7)
Affinity DataEC50:  260nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292748BDBM292748(US20260014133, Compound 9)
Affinity DataEC50:  489nMAssay Description:Inhibition of PLK4 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476157BDBM50476157(CHEMBL6074489)
Affinity DataEC50:  595nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetDNA-binding protein Ikaros/Protein cereblon(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292744BDBM292744(US20260014133, Compound 5)
Affinity DataEC50:  650nMAssay Description:Inhibition of TRKB (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed