Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 50022847
TargetProteinase-activated receptor 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655026BDBM50655026(CHEMBL6161599)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655025BDBM50655025(CHEMBL6151183)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655026BDBM50655026(CHEMBL6161599)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in mouse NIH/3T3 cells by cell-based luciferase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655021BDBM50655021(CHEMBL6162225)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655025BDBM50655025(CHEMBL6151183)
Affinity DataIC50: 15nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in mouse NIH/3T3 cells by cell-based luciferase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655021BDBM50655021(CHEMBL6162225)
Affinity DataIC50: 19nMAssay Description:Inhibition of JAK2 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655004BDBM50655004(CHEMBL6168303)
Affinity DataIC50: 21nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655013BDBM50655013(CHEMBL6143023)
Affinity DataIC50: 25nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655005BDBM50655005(CHEMBL6152236)
Affinity DataIC50: 27nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654997BDBM50654997(CHEMBL6151992)
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654977BDBM50654977(CHEMBL6134702)
Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654996BDBM50654996(CHEMBL6142388)
Affinity DataIC50: 41nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655011BDBM50655011(CHEMBL6103466)
Affinity DataIC50: 45nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654998BDBM50654998(CHEMBL6149348)
Affinity DataIC50: 46nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655031BDBM50655031(CHEMBL6149051)
Affinity DataIC50: 51nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in mouse NIH/3T3 cells by cell-based luciferase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654976BDBM50654976(CHEMBL6102807)
Affinity DataIC50: 64nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655020BDBM50655020(CHEMBL6132868)
Affinity DataIC50: 69nMAssay Description:Inhibition of JAK2 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654975BDBM50654975(CHEMBL6141565)
Affinity DataIC50: 72nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655030BDBM50655030(CHEMBL6146257)
Affinity DataIC50: 73nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in mouse NIH/3T3 cells by cell-based luciferase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654999BDBM50654999(CHEMBL6148435)
Affinity DataIC50: 80nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578824BDBM50578824(CHEMBL4860533)
Affinity DataIC50: 84nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654978BDBM50654978(CHEMBL6150775)
Affinity DataIC50: 87nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655022BDBM50655022(CHEMBL6091812)
Affinity DataIC50: 89nMAssay Description:Inhibition of JAK3 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654985BDBM50654985(CHEMBL6149938)
Affinity DataIC50: 89nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655012BDBM50655012(CHEMBL6133113)
Affinity DataIC50: 89nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654995BDBM50654995(CHEMBL6143611)
Affinity DataIC50: 89nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655029BDBM50655029(CHEMBL6149732)
Affinity DataIC50: 96nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in mouse NIH/3T3 cells by cell-based luciferase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655017BDBM50655017(CHEMBL6146774)
Affinity DataIC50: 96nMAssay Description:Inhibition of JAK1 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654986BDBM50654986(CHEMBL6143939)
Affinity DataIC50: 98nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655000BDBM50655000(CHEMBL6147359)
Affinity DataIC50: 103nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654987BDBM50654987(CHEMBL6102418)
Affinity DataIC50: 105nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655038BDBM50655038(CHEMBL6148554)
Affinity DataIC50: 109nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655014BDBM50655014(CHEMBL6102121)
Affinity DataIC50: 109nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654993BDBM50654993(CHEMBL6151003)
Affinity DataIC50: 117nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655016BDBM50655016(CHEMBL6145669)
Affinity DataIC50: 136nMAssay Description:Inhibition of JAK1 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655003BDBM50655003(CHEMBL6133040)
Affinity DataIC50: 163nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655037BDBM50655037(CHEMBL6120457)
Affinity DataIC50: 165nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655035BDBM50655035(CHEMBL6165616)
Affinity DataIC50: 168nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655027BDBM50655027(CHEMBL6161037)
Affinity DataIC50: 169nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in mouse NIH/3T3 cells by cell-based luciferase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655028BDBM50655028(CHEMBL6150017)
Affinity DataIC50: 187nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in mouse NIH/3T3 cells by cell-based luciferase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654988BDBM50654988(CHEMBL6165089)
Affinity DataIC50: 220nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655006BDBM50655006(CHEMBL6120452)
Affinity DataIC50: 223nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655018BDBM50655018(CHEMBL6134100)
Affinity DataIC50: 223nMAssay Description:Inhibition of JAK1 (unknown origin) expressed in mouse BAF3 cells assessed as antiproliferative activity by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655001BDBM50655001(CHEMBL6147204)
Affinity DataIC50: 223nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655015BDBM50655015(CHEMBL6146818)
Affinity DataIC50: 223nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655007BDBM50655007(CHEMBL6133193)
Affinity DataIC50: 274nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655039BDBM50655039(CHEMBL6142171)
Affinity DataIC50: 304nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654989BDBM50654989(CHEMBL6143246)
Affinity DataIC50: 335nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654994BDBM50654994(CHEMBL6163744)
Affinity DataIC50: 356nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProteinase-activated receptor 4(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655032BDBM50655032(CHEMBL6152880)
Affinity DataIC50: 356nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in mouse NIH/3T3 cells by cell-based luciferase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
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