Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50022679
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592488BDBM50592488(CHEMBL6102266)
Affinity DataIC50: 6nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592485BDBM50592485(CHEMBL6074548)
Affinity DataIC50: 230nMAssay Description:Antagonist activity at human MC4R assessed as inhibition of alpha MSH-stimulated cAMP release by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592485BDBM50592485(CHEMBL6074548)
Affinity DataIC50: 380nMAssay Description:Agonist activity at human PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590111BDBM50590111(CHEMBL6078430)
Affinity DataIC50: 470nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592485BDBM50592485(CHEMBL6074548)
Affinity DataKd:  480nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590111BDBM50590111(CHEMBL6078430)
Affinity DataIC50: 580nMAssay Description:Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592277BDBM50592277(CHEMBL6091967)
Affinity DataKd:  600nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592277BDBM50592277(CHEMBL6091967)
Affinity DataIC50: 600nMAssay Description:Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592277BDBM50592277(CHEMBL6091967)
Affinity DataIC50: 750nMAssay Description:Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590122BDBM50590122(CHEMBL6078439)
Affinity DataIC50: 880nMAssay Description:Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590123BDBM50590123(CHEMBL6083170)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592269BDBM50592269(CHEMBL6103238)
Affinity DataIC50: 1.30E+3nMAssay Description:Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590114BDBM50590114(CHEMBL6101895)
Affinity DataIC50: 1.30E+3nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592484BDBM50592484(CHEMBL6078129)
Affinity DataIC50: 1.40E+3nMAssay Description:Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592276BDBM50592276(CHEMBL6103476)
Affinity DataIC50: 1.50E+3nMAssay Description:Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590111BDBM50590111(CHEMBL6078430)
Affinity DataIC50: 1.60E+3nMAssay Description:Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590113BDBM50590113(CHEMBL6078437)
Affinity DataIC50: 1.60E+3nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590115BDBM50590115(CHEMBL6102462)
Affinity DataIC50: 1.90E+3nMAssay Description:Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592275BDBM50592275(CHEMBL6074439)
Affinity DataIC50: 2.30E+3nMAssay Description:Agonist activity at human PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592268BDBM50592268(CHEMBL6102382)
Affinity DataIC50: 2.60E+3nMAssay Description:Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592267BDBM50592267(CHEMBL6120618)
Affinity DataIC50: 2.60E+3nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590112BDBM50590112(CHEMBL6102939)
Affinity DataIC50: 2.90E+3nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetBranched-chain alpha-ketoacid dehydrogenase kinase(Rattus norvegicus)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50424782BDBM50424782(CHEMBL1448105)
Affinity DataIC50: 3.20E+3nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592270BDBM50592270(CHEMBL6083088)
Affinity DataIC50: 5.90E+3nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592487BDBM50592487(CHEMBL6133889)
Affinity DataIC50: 6.30E+3nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590110BDBM50590110(CHEMBL6074606)
Affinity DataIC50: 6.80E+3nMAssay Description:Agonist activity at human PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590121BDBM50590121(CHEMBL6074607)
Affinity DataIC50: 7.70E+3nMAssay Description:Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592274BDBM50592274(CHEMBL6083112)
Affinity DataIC50: 9.30E+3nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590109BDBM50590109(CHEMBL6132712)
Affinity DataIC50: 1.10E+4nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592271BDBM50592271(CHEMBL6078408)
Affinity DataIC50: 1.30E+4nMAssay Description:Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590106BDBM50590106(CHEMBL6133616)
Affinity DataIC50: 1.50E+4nMAssay Description:Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590124BDBM50590124(CHEMBL6132903)
Affinity DataIC50: 1.60E+4nMAssay Description:Agonist activity at human PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590107BDBM50590107(CHEMBL6078178)
Affinity DataIC50: 2.00E+4nMAssay Description:Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590108BDBM50590108(CHEMBL6078467)
Affinity DataIC50: 2.00E+4nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590104BDBM50590104(CHEMBL6083012)
Affinity DataIC50: 2.30E+4nMAssay Description:Agonist activity at human PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592272BDBM50592272(CHEMBL6091775)
Affinity DataIC50: 2.50E+4nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590116BDBM50590116(CHEMBL6078375)
Affinity DataIC50: 5.00E+4nMAssay Description:Agonist activity at human PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592273BDBM50592273(CHEMBL6074508)
Affinity DataIC50: 5.00E+4nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590118BDBM50590118(CHEMBL6101906)
Affinity DataIC50: 5.00E+4nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590117BDBM50590117(CHEMBL6074547)
Affinity DataIC50: 5.00E+4nMAssay Description:Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590120BDBM50590120(CHEMBL6078442)
Affinity DataIC50: 5.00E+4nMAssay Description:Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590105BDBM50590105(CHEMBL6083128)
Affinity DataIC50: 5.00E+4nMAssay Description:Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590119BDBM50590119(CHEMBL6078025)
Affinity DataIC50: 5.00E+4nMAssay Description:Agonist activity at human PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592483BDBM50592483(CHEMBL6074471)
Affinity DataIC50: 5.00E+4nMAssay Description:Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
Target[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(Human)
UT Southwestern Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592486BDBM50592486(CHEMBL6077999)
Affinity DataIC50: 5.00E+4nMAssay Description:Antagonist activity at human MC4R assessed as inhibition of alpha MSH-stimulated cAMP release by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed