Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50023098
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 195601BDBM195601(GSK321 | US11376246, Cpd ID GSK321 | US11576906, C...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of IDH1 R132G mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 404661BDBM404661(US10344004, Test compound Table 3 | US10442772, Ex...)
Affinity DataIC50: 3nMAssay Description:Inhibition of IDH1 R132L mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 195601BDBM195601(GSK321 | US11376246, Cpd ID GSK321 | US11576906, C...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 404661BDBM404661(US10344004, Test compound Table 3 | US10442772, Ex...)
Affinity DataIC50: 4nMAssay Description:Inhibition of IDH1 R132G mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 195601BDBM195601(GSK321 | US11376246, Cpd ID GSK321 | US11576906, C...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 404661BDBM404661(US10344004, Test compound Table 3 | US10442772, Ex...)
Affinity DataIC50: 5nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 404661BDBM404661(US10344004, Test compound Table 3 | US10442772, Ex...)
Affinity DataIC50: 5nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278559BDBM278559((2E)-3-(1-{[5-(2-Fluoropropan-2-yl)-3-(2,4,6-trich...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 278559BDBM278559((2E)-3-(1-{[5-(2-Fluoropropan-2-yl)-3-(2,4,6-trich...)
Affinity DataIC50: 11nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 404661BDBM404661(US10344004, Test compound Table 3 | US10442772, Ex...)
Affinity DataIC50: 16nMAssay Description:Inhibition of IDH1 R132S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503251BDBM50503251(AG-221 | Ag 221 | CC-90007 Free Base | Enasidenib ...)
Affinity DataIC50: 200nMAssay Description:Inhibition of FLAG-tagged IDH2 R172K mutant (unknown origin) extracted from baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503251BDBM50503251(AG-221 | Ag 221 | CC-90007 Free Base | Enasidenib ...)
Affinity DataIC50: 320nMAssay Description:Inhibition of FLAG-tagged IDH2 R140Q mutant (unknown origin) extracted from baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Naval Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 195601BDBM195601(GSK321 | US11376246, Cpd ID GSK321 | US11576906, C...)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed