Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50023287
TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human EGFR d746-750/T790M/C797S mutant using poly[Glu:Tyr] (4:1) as substrate incubated for 120 mins in presence of [gamma33P]-ATP by R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human EGFR T790M/C797S/L858R mutant using poly[Glu:Tyr] (4:1) as substrate incubated for 120 mins in presence of [gamma33P]-ATP by Radi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of human EGFR d746-750/C797S mutant using poly[Glu:Tyr] (4:1) as substrate incubated for 120 mins in presence of [gamma33P]-ATP by Radiome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of N-terminal GST-fused cytoplasmic domain human ALK G1269A mutant (1058 to 1620 end residues) extracted from baculovirus expression syste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of N-terminal GST-fused cytoplasmic domain human ALK L1196M mutant (1058 to 1620 end residues) extracted from baculovirus expression syste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 0.910nMAssay Description:Inhibition of N-terminal GST-fused cytoplasmic domain human ALK C1156Y mutant (1058 to 1620 end residues) extracted from baculovirus expression syste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST-fused cytoplasmic domain human wild-type ALK (1058 to 1620 end residues) extracted from baculovirus expression system us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal GST-fused human EML4-ALK (1 to 1059 residues) extracted from baculovirus expression system using Srctide as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal GST-fused human NPM1-ALK (1 to 680 residues) extracted from baculovirus expression system using Srctide as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal GST-fused cytoplasmic domain human ALK R1275Q mutant (1058 to 1620 end residues) extracted from baculovirus expression syste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human EGFR T790 M/C797S mutant using poly[Glu:Tyr] (4:1) as substrate incubated for 120 mins in presence of [gamma33P]-ATP by Radiometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human EGFR d746-750/C797A mutant using poly[Glu:Tyr] (4:1) as substrate incubated for 120 mins in presence of [gamma33P]-ATP by Radiome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of N-terminal GST-fused cytoplasmic domain human ALK F1174L mutant (1058 to 1620 end residues) extracted from baculovirus expression syste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 64nMAssay Description:Inhibition of human wild-type EGFR using poly[Glu:Tyr] (4:1) as substrate incubated for 120 mins in presence of [gamma33P]-ATP by Radiometric hotspot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed