Compile Data Set for Download or QSAR
Report error Found 65 Enz. Inhib. hit(s) with all data for entry = 50023699
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666966BDBM50666966(CHEMBL6172650)
Affinity DataIC50: 16nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666967BDBM50666967(CHEMBL6161660)
Affinity DataIC50: 20nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666965BDBM50666965(CHEMBL6176778)
Affinity DataIC50: 22nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666965BDBM50666965(CHEMBL6176778)
Affinity DataKd:  25nMAssay Description:Displacement of [3H]-1 from full length rat hippocampal membrane GluN1/GluN2A assessed as dissociation constant by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666976BDBM50666976(JNJ-78911118 | CHEMBL6176014)
Affinity DataIC50: 40nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataIC50: 42nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 393276BDBM393276(US9963434, Table 12.219 | 5-(3,4- difluorobenzenes...)
Affinity DataIC50: 50nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 393080BDBM393080(US9963434, Table 12.26 | 5-(3-chloro-4- fluorobenz...)
Affinity DataIC50: 58nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666974BDBM50666974(CHEMBL6177012)
Affinity DataIC50: 69nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataIC50: 79nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A/GluN2B expressed Xenopus oocytes measured after 2 to 6 days by two-electrode voltage clamp recor...More data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666971BDBM50666971(CHEMBL6176863)
Affinity DataIC50: 111nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666973BDBM50666973(CHEMBL6163649)
Affinity DataIC50: 119nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666977BDBM50666977(CHEMBL6176303)
Affinity DataIC50: 153nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666972BDBM50666972(CHEMBL6174428)
Affinity DataIC50: 166nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataKi:  183nMAssay Description:Displacement of [3H]-1 from full length rat hippocampal membrane GluN1/GluN2A assessed as inhibition constant by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666970BDBM50666970(CHEMBL6177304)
Affinity DataIC50: 653nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666968BDBM50666968(CHEMBL6163935)
Affinity DataIC50: 1.47E+3nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666979BDBM50666979(CHEMBL6175398)
Affinity DataIC50: 1.10E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataIC50: 1.30E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2B expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666980BDBM50666980(CHEMBL6175236)
Affinity DataIC50: 1.40E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 393276BDBM393276(US9963434, Table 12.219 | 5-(3,4- difluorobenzenes...)
Affinity DataIC50: 2.30E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2B expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666974BDBM50666974(CHEMBL6177012)
Affinity DataIC50: 2.40E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2B expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666967BDBM50666967(CHEMBL6161660)
Affinity DataIC50: 2.80E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2B expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666973BDBM50666973(CHEMBL6163649)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2B expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666969BDBM50666969(CHEMBL6176593)
Affinity DataIC50: 3.60E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666965BDBM50666965(CHEMBL6176778)
Affinity DataIC50: 4.60E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2B expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666978BDBM50666978(CHEMBL6174828)
Affinity DataIC50: 4.80E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666971BDBM50666971(CHEMBL6176863)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666972BDBM50666972(CHEMBL6174428)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666973BDBM50666973(CHEMBL6163649)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666974BDBM50666974(CHEMBL6177012)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666965BDBM50666965(CHEMBL6176778)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666968BDBM50666968(CHEMBL6163935)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666969BDBM50666969(CHEMBL6176593)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666970BDBM50666970(CHEMBL6177304)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666979BDBM50666979(CHEMBL6175398)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666976BDBM50666976(JNJ-78911118 | CHEMBL6176014)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666977BDBM50666977(CHEMBL6176303)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666978BDBM50666978(CHEMBL6174828)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666968BDBM50666968(CHEMBL6163935)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666969BDBM50666969(CHEMBL6176593)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666970BDBM50666970(CHEMBL6177304)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666971BDBM50666971(CHEMBL6176863)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666965BDBM50666965(CHEMBL6176778)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666976BDBM50666976(JNJ-78911118 | CHEMBL6176014)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666977BDBM50666977(CHEMBL6176303)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666978BDBM50666978(CHEMBL6174828)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666979BDBM50666979(CHEMBL6175398)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666972BDBM50666972(CHEMBL6174428)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
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