Compile Data Set for Download or QSAR
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Found 15 Enz. Inhib. hit(s) with all data for entry = 50029746
TargetSterol O-acyltransferase 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287512(3-(2,6-Diisopropyl-phenyl)-1-phenyl-1-{2-[8-(tetra...)
Affinity DataIC50:  16nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287511(1-Cyclohexyl-3-(2,6-diisopropyl-phenyl)-1-(2-dodec...)
Affinity DataIC50:  31nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287513(1-Benzyl-1-(2-dodecyl-2H-tetrazol-5-yl)-3-(2,4,6-t...)
Affinity DataIC50:  35nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287509(1-[2-(10-Methyl-undecyl)-2H-tetrazol-5-yl]-1-pheny...)
Affinity DataIC50:  40nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287515(1-Phenyl-1-{2-[8-(tetrahydro-pyran-2-yloxy)-octyl]...)
Affinity DataIC50:  41nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287517(3-(2,6-Diisopropyl-phenyl)-1-(2-dodecyl-2H-tetrazo...)
Affinity DataIC50:  47nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287514(1-Cyclohexyl-1-(2-dodecyl-2H-tetrazol-5-yl)-3-(2,4...)
Affinity DataIC50:  57nMAssay Description:Liver ACAT inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from the livers of cholesterol fed ratsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287518(1-(2-Dodecyl-2H-tetrazol-5-yl)-1-phenyl-3-(2,4,6-t...)
Affinity DataIC50:  61nMAssay Description:Liver ACAT inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from the livers of cholesterol fed ratsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287516(1-Phenyl-1-(2-tetradecyl-2H-tetrazol-5-yl)-3-(2,4,...)
Affinity DataIC50:  71nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287517(3-(2,6-Diisopropyl-phenyl)-1-(2-dodecyl-2H-tetrazo...)
Affinity DataIC50:  240nMAssay Description:Compound was tested for its ability to penetrate the cell wall and inhibit macrophage ACAT in cell culture using murine IC-21 macrophages (MAI)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287508(1-(2-Dodecyl-2H-tetrazol-5-yl)-1-heptyl-3-(2,4,6-t...)
Affinity DataIC50:  290nMAssay Description:Liver Acyl coenzyme A:cholesterol acyltransferase inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50005944(2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...)
Affinity DataIC50:  400nMAssay Description:Compound was tested for its ability to penetrate the cell wall and inhibit macrophage ACAT in cell culture using murine IC-21 macrophages (MAI)More data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287510(1-(2-Pentyl-2H-tetrazol-5-yl)-1-phenyl-3-(2,4,6-tr...)
Affinity DataIC50:  450nMAssay Description:Liver ACAT inhibitory activity was determined in vitro using [1-14C]-oleolyl-CoA and microsomes isolated from the livers of cholesterol fed ratsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287518(1-(2-Dodecyl-2H-tetrazol-5-yl)-1-phenyl-3-(2,4,6-t...)
Affinity DataIC50:  890nMAssay Description:Compound was tested for its ability to penetrate the cell wall and inhibit macrophage ACAT in cell culture using murine IC-21 macrophages (MAI)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSterol O-acyltransferase 1(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50287511(1-Cyclohexyl-3-(2,6-diisopropyl-phenyl)-1-(2-dodec...)
Affinity DataIC50:  3.10E+3nMAssay Description:Compound was tested for its ability to penetrate the cell wall and inhibit macrophage ACAT in cell culture using murine IC-21 macrophages (MAI)More data for this Ligand-Target Pair
In DepthDetails Article