Compile Data Set for Download or QSAR
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Report error Found 158 Enz. Inhib. hit(s) with all data for entry = 50031656
TargetSphingosine 1-phosphate receptor 4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  2.90nMAssay Description:Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Affinity DataIC50:  6nMAssay Description:Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 5(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Affinity DataIC50:  142nMAssay Description:Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Affinity DataIC50:  1.96E+3nMAssay Description:Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Affinity DataIC50:  2.07E+3nMAssay Description:Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Affinity DataEC50:  5.70nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 5(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.200nMAssay Description:Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316768((Z,Z)-5-[3-Chloro-4-((2S)-2,3-dihydroxy-propoxy)-b...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSphingosine 1-phosphate receptor 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Affinity DataEC50:  9.10nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  44nMAssay Description:Agonist activity at human recombinant S1P2 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSphingosine 1-phosphate receptor 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316768((Z,Z)-5-[3-Chloro-4-((2S)-2,3-dihydroxy-propoxy)-b...)
Affinity DataEC50:  174nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Affinity DataEC50:  123nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.100nMAssay Description:Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.200nMAssay Description:Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSphingosine 1-phosphate receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.700nMAssay Description:Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316707(CHEMBL1097182 | rac-(Z,Z)-5-[4-(2,3-Dihydroxy-prop...)
Affinity DataEC50:  240nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316708((Z,Z)-5-[4-(3-Hydroxy-propoxy)-benzylidene]-2-isop...)
Affinity DataEC50:  68nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316709((Z,Z)-5-[4-(2-Hydroxy-ethoxy)-benzylidene]-2-isopr...)
Affinity DataEC50:  114nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316710((Z,Z)-5-[4-(3-Hydroxy-propyl)-benzylidene]-2-isopr...)
Affinity DataEC50:  54nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316711((Z,Z)-5-[4-(2-Hydroxy-ethyl)-benzylidene]-2-isopro...)
Affinity DataEC50:  59nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316712((Z,Z)-5-(4-Hydroxymethyl-benzylidene)-2-isopropyli...)
Affinity DataEC50:  86nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316713((Z,Z)-2-Isopropylimino-5-(2-methoxy-benzylidene)-3...)
Affinity DataEC50:  6.69E+3nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316714((Z,Z)-5-(2-Chloro-benzylidene)-2-isopropylimino-3-...)
Affinity DataEC50:  2.58E+3nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316715((Z,Z)-2-Isopropylimino-5-(2-methyl-benzylidene)-3-...)
Affinity DataEC50:  5.79E+3nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316716((Z,Z)-5-(3,4-Dihydroxy-benzylidene)-2-isopropylimi...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316717((Z,Z)-5-(3-Hydroxy-4-methoxy-benzylidene)-2-isopro...)
Affinity DataEC50:  212nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316718((Z,Z)-5-(3-Hydroxy-benzylidene)-2-isopropylimino-3...)
Affinity DataEC50:  103nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316719((Z,Z)-2-Isopropylimino-5-(3-methoxy-benzylidene)-3...)
Affinity DataEC50:  35nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316720((Z,Z)-5-(4-Bromo-benzylidene)-2-isopropylimino-3-p...)
Affinity DataEC50:  136nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316721((Z,Z)-5-(4-Dimethylamino-benzylidene)-2-isopropyli...)
Affinity DataEC50:  165nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316722((Z,Z)-5-(3,4-Dimethoxy-benzylidene)-2-isopropylimi...)
Affinity DataEC50:  1.39E+3nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316723((Z,Z)-2-Isopropylimino-5-(4-methoxy-benzylidene)-3...)
Affinity DataEC50:  106nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316724((Z,Z)-5-(4-Hydroxy-3-methoxy-benzylidene)-2-isopro...)
Affinity DataEC50:  335nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316725((Z,Z)-5-(4-Hydroxy-3-methyl-benzylidene)-2-isoprop...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316726((Z,Z)-5-(3-Fluoro-4-hydroxy-benzylidene)-2-isoprop...)
Affinity DataEC50:  99nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316727((Z,Z)-5-(4-Hydroxy-benzylidene)-2-isopropylimino-3...)
Affinity DataEC50:  95nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316728((Z,Z)-5-Benzylidene-2-isopropylimino-3-phenyl-thia...)
Affinity DataEC50:  317nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316729((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Affinity DataEC50:  212nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316730((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Affinity DataEC50:  183nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316731((Z,Z)-3-Benzyl-5-(3-chloro-4-hydroxy-benzylidene)-...)
Affinity DataEC50:  674nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316732((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Affinity DataEC50:  228nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316733((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-3-(2,4-di...)
Affinity DataEC50:  525nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316734((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Affinity DataEC50:  127nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316735((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Affinity DataEC50:  514nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316736((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Affinity DataEC50:  428nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316737((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-3-(3-chlo...)
Affinity DataEC50:  144nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316738((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-3-(3-chlo...)
Affinity DataEC50:  246nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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