Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50039216
TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321650((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  120nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321650((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  240nMAssay Description:Inhibition of ABL1 by Z-lite assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321651((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  300nMAssay Description:Inhibition of ABL1 by Z-lite assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321649(3,6-di(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine | ...)
Affinity DataIC50:  440nMAssay Description:Inhibition of ABL1 by Z-lite assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321654(3-(1H-pyrazol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2...)
Affinity DataIC50:  480nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321655(3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321654(3-(1H-pyrazol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321656((3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321650((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321651((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321657(3-phenyl-6-(pyridin-4-yl)imidazo[1,2-a]pyrazine | ...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of GSK3-beta at 10 uM by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321681((3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321649(3,6-di(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine | ...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321655(3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of GSK3-beta at 10 uM by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321652(3-PHENYL-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321655(3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321649(3,6-di(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine | ...)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321679(4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)a...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321678(6-(5-methyl-1H-pyrazol-4-yl)-3-(1H-pyrazol-4-yl)im...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321653(3-(1-methyl-1H-pyrazol-4-yl)-6-(1H-pyrazol-4-yl)im...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321677(6-phenyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321669(4-(4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidin-3...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321653(3-(1-methyl-1H-pyrazol-4-yl)-6-(1H-pyrazol-4-yl)im...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321668(4-(3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidin-3...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321676(3-(1H-pyrazol-4-yl)-6-(pyridin-4-yl)imidazo[1,2-a]...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321673(4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)a...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321680(3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)a...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321656((3-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321652(3-PHENYL-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321651((4-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321675(6-(1H-pyrazol-4-yl)-3-(1H-pyrrol-2-yl)imidazo[1,2-...)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321667((3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidin-3-y...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321657(3-phenyl-6-(pyridin-4-yl)imidazo[1,2-a]pyrazine | ...)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321659(6-(1-methyl-1H-pyrazol-4-yl)-3-phenylimidazo[1,2-a...)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321674((4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)...)
Affinity DataIC50:  9.60E+4nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321671(3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)b...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321665(6-(1H-pyrazol-4-yl)-3-(pyridin-3-yl)imidazo[1,2-a]...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321672(3-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)a...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321658(3-phenyl-6-(1H-pyrazol-3-yl)imidazo[1,2-a]pyrazine...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321663(3-phenyl-6-(pyridin-2-yl)imidazo[1,2-a]pyrazine | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321666(3-(4-phenoxyphenyl)-6-(1H-pyrazol-4-yl)imidazo[1,2...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321670(4-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)b...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321662(6-(1H-indol-3-yl)-3-phenylimidazo[1,2-a]pyrazine |...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321661(3-phenyl-6-(1H-pyrrol-2-yl)imidazo[1,2-a]pyrazine ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321664(3-phenyl-6-(pyridin-3-yl)imidazo[1,2-a]pyrazine | ...)
Affinity DataIC50:  1.39E+5nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321660(6-(1-benzyl-1H-pyrazol-4-yl)-3-phenylimidazo[1,2-a...)
Affinity DataIC50:  2.08E+5nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed