Compile Data Set for Download or QSAR
Report error Found 72 Enz. Inhib. hit(s) with all data for entry = 50003853
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 35229BDBM35229(Desmethylimipramine | 3-(10,11-dihydro-5H-dibenzo[...)
Affinity DataIC50: 70nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 77970BDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 90nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50020707BDBM50020707(CHEMBL287064 | Nomelidine | [3-(4-Bromo-phenyl)-3-...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50020707BDBM50020707(CHEMBL287064 | Nomelidine | [3-(4-Bromo-phenyl)-3-...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027985BDBM50027985((cis/trans) mixture)[3-(4-Chloro-phenyl)-3-pyridin...)
Affinity DataIC50: 120nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027985BDBM50027985((cis/trans) mixture)[3-(4-Chloro-phenyl)-3-pyridin...)
Affinity DataIC50: 120nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027998BDBM50027998(cis -[3-(2-Bromo-phenyl)-3-pyridin-3-yl-allyl]-met...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50010859BDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50017666BDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027989BDBM50027989(cis -Dimethyl-[3-(4-methylsulfanyl-phenyl)-3-pyrid...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027985BDBM50027985((cis/trans) mixture)[3-(4-Chloro-phenyl)-3-pyridin...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027985BDBM50027985((cis/trans) mixture)[3-(4-Chloro-phenyl)-3-pyridin...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027997BDBM50027997(cis -[3-(2,4-Dichloro-phenyl)-3-pyridin-3-yl-allyl...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027998BDBM50027998(cis -[3-(2-Bromo-phenyl)-3-pyridin-3-yl-allyl]-met...)
Affinity DataIC50: 600nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 76298BDBM76298(SMR001230852 | MLS002153522 | ALAPROCLATE HYDROCHL...)
Affinity DataIC50: 700nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027980BDBM50027980(cis -[3-(4-Methoxy-phenyl)-3-pyridin-3-yl-allyl]-d...)
Affinity DataIC50: 800nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 77970BDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 900nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50028000BDBM50028000([3-(3-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl...)
Affinity DataIC50: 900nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027983BDBM50027983(cis -[3-(3-Bromo-phenyl)-3-pyridin-3-yl-allyl]-met...)
Affinity DataIC50: 900nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027981BDBM50027981(cis -[3-(4-Iodo-phenyl)-3-pyridin-3-yl-allyl]-dime...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010859BDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027983BDBM50027983(cis -[3-(3-Bromo-phenyl)-3-pyridin-3-yl-allyl]-met...)
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027996BDBM50027996(cis -[3-(4-Fluoro-phenyl)-3-pyridin-3-yl-allyl]-me...)
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50020707BDBM50020707(CHEMBL287064 | Nomelidine | [3-(4-Bromo-phenyl)-3-...)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027987BDBM50027987(cis -[3-(2,4-Dichloro-phenyl)-3-pyridin-3-yl-allyl...)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027996BDBM50027996(cis -[3-(4-Fluoro-phenyl)-3-pyridin-3-yl-allyl]-me...)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50020707BDBM50020707(CHEMBL287064 | Nomelidine | [3-(4-Bromo-phenyl)-3-...)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027994BDBM50027994(cis -[4-(3-Dimethylamino-1-pyridin-2-yl-propenyl)-...)
Affinity DataIC50: 1.60E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027982BDBM50027982(cis -[3-(3-Fluoro-phenyl)-3-pyridin-3-yl-allyl]-di...)
Affinity DataIC50: 1.60E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 66978BDBM66978(Zimelidine (E-isomer) | Zimelidine (Z-isomer) | (E...)
Affinity DataIC50: 1.70E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027990BDBM50027990(cis -[3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-eth...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027984BDBM50027984(cis -Dimethyl-[3-pyridin-3-yl-3-(4-trifluoromethyl...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50028002BDBM50028002(cis -[3-(4-Chloro-phenyl)-3-pyridin-3-yl-allyl]-di...)
Affinity DataIC50: 2.10E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027978BDBM50027978(cis -[3-(2-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dim...)
Affinity DataIC50: 2.20E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027982BDBM50027982(cis -[3-(3-Fluoro-phenyl)-3-pyridin-3-yl-allyl]-di...)
Affinity DataIC50: 2.20E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027997BDBM50027997(cis -[3-(2,4-Dichloro-phenyl)-3-pyridin-3-yl-allyl...)
Affinity DataIC50: 2.30E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027986BDBM50027986(cis -Dimethyl-(3-pyridin-3-yl-3-p-tolyl-allyl)-ami...)
Affinity DataIC50: 2.40E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027992BDBM50027992(cis -[3-(3-Chloro-phenyl)-3-pyridin-3-yl-allyl]-di...)
Affinity DataIC50: 2.60E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50028003BDBM50028003(cis -[3-(4-Chloro-phenyl)-3-pyridin-4-yl-allyl]-di...)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027988BDBM50027988(cis -[3-(4-Isopropoxy-phenyl)-3-pyridin-4-yl-allyl...)
Affinity DataIC50: 3.50E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027993BDBM50027993(cis -Dimethyl-(3-phenyl-3-pyridin-3-yl-allyl)-amin...)
Affinity DataIC50: 3.70E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027991BDBM50027991(cis -[3-(4-Fluoro-phenyl)-3-pyridin-3-yl-allyl]-di...)
Affinity DataIC50: 4.00E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027978BDBM50027978(cis -[3-(2-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dim...)
Affinity DataIC50: 4.20E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50028000BDBM50028000([3-(3-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl...)
Affinity DataIC50: 4.20E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017666BDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 4.70E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50020706BDBM50020706(cis -[3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dim...)
Affinity DataIC50: 6.10E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50020706BDBM50020706(cis -[3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dim...)
Affinity DataIC50: 6.10E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50027999BDBM50027999(cis -4-(3-Dimethylamino-1-pyridin-3-yl-propenyl)-b...)
Affinity DataIC50: 7.40E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50028001BDBM50028001(cis -Dimethyl-(3-pyridin-4-yl-3-m-tolyl-allyl)-ami...)
Affinity DataIC50: 8.80E+3nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50028002BDBM50028002(cis -[3-(4-Chloro-phenyl)-3-pyridin-3-yl-allyl]-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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