Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50004989
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031196BDBM50031196(2-[3-Methyl-2-({1-[3-methyl-2-(4-chlorophenyl-sulf...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031185BDBM50031185(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031203BDBM50031203(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031187BDBM50031187(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031198BDBM50031198(1-(4-(((S)-1-((S)-2-(((S)-1-(benzo[d]oxazol-2-yl)-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031188BDBM50031188(2-[(S)-3-Methyl-2-({(S)-1-[(S)-3-methyl-2-(4-trifl...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031209BDBM50031209(N1-((S)-1-((S)-2-(((S)-1-(benzo[d]oxazol-2-yl)-3-m...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031217BDBM50031217(tert-butyl 4-(((S)-1-((S)-2-(((S)-1-(benzo[d]oxazo...)
Affinity DataKi:  0.340nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031197BDBM50031197(2-[(S)-3-Methyl-2-({(S)-1-[(S)-3-methyl-2-(4-sulfa...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031210BDBM50031210(2-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-m...)
Affinity DataKi:  0.370nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031192BDBM50031192([(S)-1-((S)-2-{(S)-1-[5-(tert-Butyl-dimethyl-silan...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031201BDBM50031201((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031194BDBM50031194((S)-1-[(S)-2-(4-Benzenesulfonylaminocarbonyl-benzo...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031191BDBM50031191(2-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-m...)
Affinity DataKi:  0.550nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031193BDBM50031193(1-[2-(4-Benzenesulfonamido-carbamide-benzoylamino)...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031207BDBM50031207(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031205BDBM50031205((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  0.660nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031211BDBM50031211((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  0.660nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031215BDBM50031215((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  0.810nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031202BDBM50031202([2-(2-{[1-(2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  1nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031200BDBM50031200([2-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031214BDBM50031214(((S)-1-{(S)-2-[(S)-1-(5-Chloro-benzooxazole-2-carb...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031195BDBM50031195((S)-1-[(S)-3-methyl-2-(4-sulfamoyl-benzoylamino)-b...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031189BDBM50031189((S)-1-{(S)-3-Methyl-2-[4-(propane-2-sulfonylaminoc...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031206BDBM50031206(((S)-1-{(S)-2-[(S)-1-(5-Cyano-benzooxazole-2-carbo...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031213BDBM50031213(((S)-1-{(S)-2-[(S)-1-(5-Methoxy-benzooxazole-2-car...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031186BDBM50031186(N-((S)-1-{(S)-2-[(S)-1-(Benzooxazole-2-carbonyl)-2...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031204BDBM50031204(((S)-1-{(S)-2-[(S)-1-(5-Hydroxymethyl-benzooxazole...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031199BDBM50031199(((S)-1-{(S)-2-[(S)-1-(Benzooxazole-2-carbonyl)-2-m...)
Affinity DataKi:  3nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50407523BDBM50407523(CHEMBL1237168)
Affinity DataKi:  4.20nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031212BDBM50031212([2-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031190BDBM50031190((S)-1-[(S)-2-(4-Methanesulfonylaminocarbonyl-benzo...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031208BDBM50031208(N-((S)-1-{(S)-2-[(S)-1-(Benzooxazole-2-carbonyl)-2...)
Affinity DataKi:  11nMAssay Description:Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymotrypsin-like elastase family member 2A(Pig)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031187BDBM50031187(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi:  26nMAssay Description:Binding affinity towards porcine pancreatic elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymotrypsinogen A(Bovine)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031187BDBM50031187(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi:  92nMAssay Description:Binding affinity towards chymotrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031187BDBM50031187(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031187BDBM50031187(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity towards trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPapain(Papaya)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031187BDBM50031187(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi: >2.00E+5nMAssay Description:Binding affinity towards papainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031187BDBM50031187(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi: >2.00E+5nMAssay Description:Biological activity was measured against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholine O-acetyltransferase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031187BDBM50031187(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi: >2.00E+6nMAssay Description:Binding affinity towards AcetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin G(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031187BDBM50031187(2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi: >2.00E+6nMAssay Description:Binding affinity towards cathepsin GMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed