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Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50005174
TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033772(CHEMBL354432 | ethyl 8-ethyl-8-hydroxy-9,12-dioxo-...)
Affinity DataIC50:  700nMAssay Description:Inhibitory concentration of the compound against topoisomerase I obtained from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033802((R)-4-Ethyl-7-[5-fluoro-2-oxo-1,2-dihydro-indol-(3...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033787(4-Ethyl-7-[5-fluoro-2-oxo-1,2-dihydro-indol-(3E)-y...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033771(4-Ethyl-4-hydroxy-10-iodo-3,13-dioxo-3,4,12,13-tet...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory concentration of the compound against topoisomerase I obtained from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033785((R)-7-[5,6-Difluoro-2-oxo-1,2-dihydro-indol-(3E)-y...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033776(7-[5,6-Difluoro-2-oxo-1,2-dihydro-indol-(3E)-ylide...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033783(4-Ethyl-8,9-difluoro-4-hydroxy-3,13-dioxo-3,4,12,1...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory concentration of the compound against topoisomerase I obtained from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033797((R)-4-Ethyl-4-hydroxy-7-[5-methyl-2-oxo-1,2-dihydr...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033798((R)-4-Ethyl-4-hydroxy-9-methyl-3,13-dioxo-3,4,12,1...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory concentration of the compound against topoisomerase I obtained from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033796((R)-4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahy...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory concentration of the compound against topoisomerase I obtained from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033801(4-Ethyl-4-hydroxy-9-iodo-3,13-dioxo-3,4,12,13-tetr...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory concentration of the compound against topoisomerase I obtained from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033775((R)-4-Ethyl-9-fluoro-4-hydroxy-3,13-dioxo-3,4,12,1...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibitory concentration of the compound against topoisomerase I obtained from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033789(4-Ethyl-9-fluoro-4-hydroxy-3,13-dioxo-3,4,12,13-te...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibitory concentration of the compound against topoisomerase I obtained from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033778((R)-4-Ethyl-4-hydroxy-7-[2-oxo-1,2-dihydro-indol-(...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033769(4-Ethyl-4-hydroxy-7-[2-oxo-1,2-dihydro-indol-(3E)-...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033780((R)-4-Ethyl-4-hydroxy-7-[5-iodo-2-oxo-1,2-dihydro-...)
Affinity DataIC50:  1.21E+4nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033784(8-ethyl-8-hydroxy-9,12-dioxo-2,3,8,9,12,14-hexahyd...)
Affinity DataIC50:  2.41E+4nMAssay Description:Inhibitory concentration of the compound against topoisomerase I obtained from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033799(4-Ethyl-4-hydroxy-7-[7-oxo-2,3,6,7-tetrahydro-[1,4...)
Affinity DataIC50:  2.96E+4nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033791(4-Ethyl-4-hydroxy-7-[5-iodo-2-oxo-1,2-dihydro-indo...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033773(7-[5-Chloro-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033800(4-Ethyl-4-hydroxy-7-[5-nitro-2-oxo-1,2-dihydro-ind...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033795((S)-4-Ethyl-9-fluoro-4-hydroxy-3,13-dioxo-3,4,12,1...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration of the compound against topoisomerase I obtained from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033794(4-Ethyl-4-hydroxy-7-[6-methoxy-2-oxo-1,2-dihydro-i...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033792((R)-7-[5-Bromo-2-oxo-1,2-dihydro-indol-(3E)-yliden...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033793(4-Ethyl-4-hydroxy-7-[5,6,7-trifluoro-2-oxo-1,2-dih...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033790((R)-4-Ethyl-4-hydroxy-7-[6-methylsulfanyl-2-oxo-1,...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033770((R)-7-[7-Chloro-2-oxo-1,2-dihydro-indol-(3E)-ylide...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033786(4-Ethyl-4-hydroxy-7-[1-methyl-2-oxo-1,2-dihydro-in...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033779((R)-4-Ethyl-4-hydroxy-7-[5-methyl-7-nitro-2-oxo-1,...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033781((R)-4-Ethyl-4-hydroxy-7-[7-methyl-2-oxo-1,2-dihydr...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033782(4-Ethyl-7-[6-fluoro-7-methyl-2-oxo-1,2-dihydro-ind...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033777((S)-4-Ethyl-7-[5-fluoro-2-oxo-1,2-dihydro-indol-(3...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033774((R)-4-Ethyl-4-hydroxy-7-[2-oxo-6-trifluoromethoxy-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033788((S)-4-Ethyl-4-hydroxy-7-[2-oxo-1,2-dihydro-indol-(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed