Compile Data Set for Download or QSAR
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Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50005247
TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034841((S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoyl)-p...)
Affinity DataIC50:  0.700nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034846((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  0.740nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  0.810nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  1.5nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  1.60nMAssay Description:The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  2nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using ANF(atrial natriuretic factor) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  4.80nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034842((2R,4S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034846((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  5nMAssay Description:The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034846((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  5.30nMAssay Description:The compound was tested in vitro for inhibition of neutral endopeptidase by using ANF(atrial natriuretic factor) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  8.30nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using ANF(atrial natriuretic factor) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017733((2S,4S)-2-Benzyl-4-(2-carboxy-ethylcarbamoyl)-5-ph...)
Affinity DataIC50:  9nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034855((2S,4S)-5-Biphenyl-4-yl-4-(2-carboxy-2-hydroxy-eth...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034856((2S,4S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoy...)
Affinity DataIC50:  19nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034850((R)-2-[(S)-3-Biphenyl-4-yl-2-(2-carboxy-2-hydroxy-...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034865((2S,4S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  27nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034848(4-(2-Carboxy-ethylcarbamoyl)-2-(4-pyrrol-1-yl-benz...)
Affinity DataIC50:  36nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034840((2R,4S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoy...)
Affinity DataIC50:  41nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034844((2R,4R)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoy...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034844((2R,4R)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoy...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034867((2S,4S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoy...)
Affinity DataIC50:  46nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034858((2R,4R)-5-Biphenyl-4-yl-4-(4-carboxy-butyrylamino)...)
Affinity DataIC50:  49nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034847(5-Biphenyl-4-yl-2-biphenyl-4-ylmethyl-4-(2-carboxy...)
Affinity DataIC50:  49nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034861((2S,4S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoy...)
Affinity DataIC50:  54nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034862((2S,4S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoy...)
Affinity DataIC50:  54nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034853((R)-2-[(S)-3-Biphenyl-4-yl-2-(2-carboxy-ethylcarba...)
Affinity DataIC50:  66nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034854((2R,4S)-5-Biphenyl-4-yl-4-(4-carboxy-butyrylamino)...)
Affinity DataIC50:  90nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034843((2R,4S)-5-Biphenyl-4-yl-4-(2-carboxy-acetylamino)-...)
Affinity DataIC50:  92nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034864((S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-p...)
Affinity DataIC50:  99nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034841((S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoyl)-p...)
Affinity DataIC50:  155nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034841((S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoyl)-p...)
Affinity DataIC50:  155nMAssay Description:The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034868((2S,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034863(4-(2-Carboxy-ethylcarbamoyl)-2-(4-phenoxy-benzyl)-...)
Affinity DataIC50:  203nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034857((2R,4S)-5-Biphenyl-4-yl-4-(5-carboxy-pentanoylamin...)
Affinity DataIC50:  324nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034859(4-(2-Carboxy-ethylcarbamoyl)-2-(4-isopropyl-benzyl...)
Affinity DataIC50:  489nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034860(4-[4-Carboxy-2-(4-pyrrol-1-yl-benzyl)-5-(4-pyrrol-...)
Affinity DataIC50:  515nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034846((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  700nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034845((2R,4R)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoy...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034845((2R,4R)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoy...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034849(4-(2-Carboxy-ethylcarbamoyl)-2-(4-thiazol-2-yl-ben...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034866(2-Benzyl-4-(2-carboxy-ethylcarbamoyl)-5-phenyl-pen...)
Affinity DataIC50:  1.20E+3nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017733((2S,4S)-2-Benzyl-4-(2-carboxy-ethylcarbamoyl)-5-ph...)
Affinity DataIC50:  1.20E+3nMAssay Description:The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034852((2R,4S)-2-Benzyl-4-(3-carboxy-propionylamino)-5-ph...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed