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Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50005735
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040348(8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-puri...)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition of cGMP hydrolysis by PDE 5AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040371(1,3-Bis-cyclopropylmethyl-7-(4-methoxy-benzyl)-8-[...)
Affinity DataIC50:  50nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040346(8-Amino-1,3-bis-cyclopropylmethyl-7-(4-methoxy-ben...)
Affinity DataIC50:  140nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040348(8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-puri...)
Affinity DataIC50:  170nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040379(CHEMBL423559 | N'-[1,3-Bis-cyclopropylmethyl-7-(4-...)
Affinity DataIC50:  240nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040354(8-Amino-1,3-bis-cyclopropylmethyl-7-(3,4-dimethoxy...)
Affinity DataIC50:  300nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040356(8-Amino-1,3-bis-cyclopropylmethyl-7-(4-methoxy-ben...)
Affinity DataIC50:  440nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50020874((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...)
Affinity DataIC50:  500nMAssay Description:Inhibition of phosphodiesterase 5AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040371(1,3-Bis-cyclopropylmethyl-7-(4-methoxy-benzyl)-8-[...)
Affinity DataIC50:  610nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040362(8-Amino-7-benzyl-1,3-bis-cyclopropylmethyl-3,7-dih...)
Affinity DataIC50:  840nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040372(8-Amino-7-(4-chloro-benzenesulfonyl)-1,3-bis-cyclo...)
Affinity DataIC50:  900nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14363(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Affinity DataIC50:  900nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040377(2-(2-Propoxy-phenyl)-1,7-dihydro-purin-6-one | 2-(...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of phosphodiesterase 5AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040359(CHEMBL145159 | N-[1,3-Bis-cyclopropylmethyl-7-(4-m...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040349(8-Amino-1,3-bis-cyclopropylmethyl-7-(toluene-4-sul...)
Affinity DataIC50:  1.20E+3nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040345(CHEMBL146165 | N-(1,3-Bis-cyclopropylmethyl-2,6-di...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040359(CHEMBL145159 | N-[1,3-Bis-cyclopropylmethyl-7-(4-m...)
Affinity DataIC50:  2.20E+3nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040351(8-Amino-1,3-bis-cyclopropylmethyl-7-propyl-3,7-dih...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040355(1,3-Bis(cyclopropylmethyl)-8-bis[(4-nitrophenylsul...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040344(8-Amino-1,3-bis-cyclopropylmethyl-7-(propane-2-sul...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040362(8-Amino-7-benzyl-1,3-bis-cyclopropylmethyl-3,7-dih...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040350(8-Amino-1,3-bis-cyclopropylmethyl-7-methanesulfony...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040352(1,3-Bis-cyclopropylmethyl-8-[1-methyl-pyrrolidin-(...)
Affinity DataIC50:  3.00E+3nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040343(8-Amino-1,3-bis-cyclopropylmethyl-7-isobutyl-3,7-d...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040369(8-Amino-7-benzenesulfonyl-1,3-bis-cyclopropylmethy...)
Affinity DataIC50:  3.60E+3nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040349(8-Amino-1,3-bis-cyclopropylmethyl-7-(toluene-4-sul...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040372(8-Amino-7-(4-chloro-benzenesulfonyl)-1,3-bis-cyclo...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Bovine)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040375(1,3-Bis(cyclopropylmethyl)-8-bis[(4-nitrophenylsul...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of phosphodiesterase 2 at 100 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040376(1,3-Bis(cyclopropylmethyl)-8-bis[(phenylsulfonyl)a...)
Affinity DataIC50:  6.50E+3nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040366(8-Amino-1,3-bis-cyclopropylmethyl-7-(4-nitro-benzy...)
Affinity DataIC50:  8.30E+3nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040365(8-Amino-1,3-bis-cyclopropylmethyl-7-naphthalen-1-y...)
Affinity DataIC50:  9.80E+3nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040358(5-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040343(8-Amino-1,3-bis-cyclopropylmethyl-7-isobutyl-3,7-d...)
Affinity DataIC50:  1.10E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM14363(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of phosphodiesterase 1C at 100 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040374(8-Amino-1,3-bis-cyclopropylmethyl-7-(3,4,5-trimeth...)
Affinity DataIC50:  1.30E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040351(8-Amino-1,3-bis-cyclopropylmethyl-7-propyl-3,7-dih...)
Affinity DataIC50:  1.40E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM10847(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of adenosine binding to A1 receptorof rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040368(8-Amino-1,3-bis-cyclopropylmethyl-7-methyl-3,7-dih...)
Affinity DataIC50:  2.00E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040363(1,3-Bis(cyclopropylmethyl)-8-bis[(phenylsulfonyl)a...)
Affinity DataIC50:  2.00E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040357(CHEMBL358574 | N-(1,3-Bis-cyclopropylmethyl-2,6-di...)
Affinity DataIC50:  2.20E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040355(1,3-Bis(cyclopropylmethyl)-8-bis[(4-nitrophenylsul...)
Affinity DataIC50:  2.40E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040350(8-Amino-1,3-bis-cyclopropylmethyl-7-methanesulfony...)
Affinity DataIC50:  3.20E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040375(1,3-Bis(cyclopropylmethyl)-8-bis[(4-nitrophenylsul...)
Affinity DataIC50:  3.40E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040347(CHEMBL142922 | N-[1,3-Bis-cyclopropylmethyl-2,6-di...)
Affinity DataIC50:  3.70E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040364(8-Amino-1,3-bis-cyclopropylmethyl-7-(3-trifluorome...)
Affinity DataIC50:  3.70E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040344(8-Amino-1,3-bis-cyclopropylmethyl-7-(propane-2-sul...)
Affinity DataIC50:  3.80E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040360(8-Amino-1,3-bis-cyclopropylmethyl-7-(4-nitro-benze...)
Affinity DataIC50:  3.80E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040367(8-Amino-1,3-bis-cyclopropylmethyl-7-(2,5-dimethoxy...)
Affinity DataIC50:  4.00E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040353(8-Amino-1,3-bis-cyclopropylmethyl-7-(4-trifluorome...)
Affinity DataIC50:  4.90E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040373(CHEMBL344720 | N-(1,3-Bis-cyclopropylmethyl-7-meth...)
Affinity DataIC50:  5.30E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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