Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50036131
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50228246BDBM50228246(Indolidan)
Affinity DataIC50: 80nMAssay Description:Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 15296BDBM15296(Milrinone | CHEMBL189 | 6-methyl-2-oxo-5-pyridin-4...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045013BDBM50045013(2-(2-Butoxy-phenyl)-3H-imidazo[4,5-b]pyridine | CH...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045012BDBM50045012(2-(2-Pentyloxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14363BDBM14363(5-(2-propoxyphenyl)-2H,3H,7H-[1,2,3]triazolo[4,5-d...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045018BDBM50045018(2-(2-Pentyloxy-phenyl)-3H-imidazo[4,5-c]pyridine; ...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045017BDBM50045017(2-[2-(3-Chloro-propoxy)-phenyl]-3H-imidazo[4,5-b]p...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045016BDBM50045016(2-(2-Isobutoxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibition of PDE-IV isolated from guinea pig ventricle.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045016BDBM50045016(2-(2-Isobutoxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045009BDBM50045009(2-(2-Hexyloxy-phenyl)-3H-imidazo[4,5-b]pyridine | ...)
Affinity DataIC50: 4.00E+3nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045015BDBM50045015(2-(2-Benzyloxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Affinity DataIC50: 4.00E+3nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045014BDBM50045014(2-(2-Cyclopropylmethoxy-phenyl)-3H-imidazo[4,5-b]p...)
Affinity DataIC50: 6.00E+3nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045012BDBM50045012(2-(2-Pentyloxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Affinity DataIC50: 6.00E+3nMAssay Description:In vitro inhibition of PDE-IV isolated from guinea pig ventricle.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045013BDBM50045013(2-(2-Butoxy-phenyl)-3H-imidazo[4,5-b]pyridine | CH...)
Affinity DataIC50: 6.00E+3nMAssay Description:In vitro inhibition of PDE-IV isolated from guinea pig ventricle.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50000315BDBM50000315((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045026BDBM50045026(2-(2-Propoxy-phenyl)-3H-imidazo[4,5-b]pyridine | C...)
Affinity DataIC50: 6.00E+3nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045015BDBM50045015(2-(2-Benzyloxy-phenyl)-3H-imidazo[4,5-b]pyridine |...)
Affinity DataIC50: 8.00E+3nMAssay Description:In vitro inhibition of PDE-IV isolated from guinea pig ventricle.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045017BDBM50045017(2-[2-(3-Chloro-propoxy)-phenyl]-3H-imidazo[4,5-b]p...)
Affinity DataIC50: 9.00E+3nMAssay Description:In vitro inhibition of PDE-IV isolated from guinea pig ventricle.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045026BDBM50045026(2-(2-Propoxy-phenyl)-3H-imidazo[4,5-b]pyridine | C...)
Affinity DataIC50: 1.10E+4nMAssay Description:In vitro inhibition of PDE-IV isolated from guinea pig ventricle.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045021BDBM50045021(2-(2-Cyclopentyloxy-phenyl)-3H-imidazo[4,5-b]pyrid...)
Affinity DataIC50: 1.50E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045009BDBM50045009(2-(2-Hexyloxy-phenyl)-3H-imidazo[4,5-b]pyridine | ...)
Affinity DataIC50: 1.60E+4nMAssay Description:In vitro inhibition of PDE-IV isolated from guinea pig ventricle.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045024BDBM50045024(2-(2-Ethoxy-phenyl)-3H-imidazo[4,5-b]pyridine | CH...)
Affinity DataIC50: 1.80E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045021BDBM50045021(2-(2-Cyclopentyloxy-phenyl)-3H-imidazo[4,5-b]pyrid...)
Affinity DataIC50: 1.90E+4nMAssay Description:In vitro inhibition of PDE-IV isolated from guinea pig ventricle.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50000056BDBM50000056(CHEMBL286020 | 2-(4-Methanesulfinyl-2-methoxy-phen...)
Affinity DataIC50: 2.10E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045011BDBM50045011(3-[2-(3H-Imidazo[4,5-b]pyridin-2-yl)-phenoxy]-prop...)
Affinity DataIC50: 2.40E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045008BDBM50045008(2-(2-Propylsulfanyl-phenyl)-3H-imidazo[4,5-b]pyrid...)
Affinity DataIC50: 2.40E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045019BDBM50045019([2-(3H-Imidazo[4,5-b]pyridin-2-yl)-phenyl]-propyl-...)
Affinity DataIC50: 2.60E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045028BDBM50045028(2-(2-Propoxy-phenyl)-imidazo[1,2-a]pyrimidine | CH...)
Affinity DataIC50: 3.30E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045027BDBM50045027(CHEMBL543042 | CHEMBL236937 | 2-(2-Methoxy-phenyl)...)
Affinity DataIC50: 3.40E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045007BDBM50045007(2-(3H-Imidazo[4,5-b]pyridin-2-yl)-phenol | CHEMBL2...)
Affinity DataIC50: 3.70E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045014BDBM50045014(2-(2-Cyclopropylmethoxy-phenyl)-3H-imidazo[4,5-b]p...)
Affinity DataIC50: 3.70E+4nMAssay Description:In vitro inhibition of PDE-IV isolated from guinea pig ventricle.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045023BDBM50045023(Acetic acid 2-(3H-imidazo[4,5-b]pyridin-2-yl)-phen...)
Affinity DataIC50: 4.00E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045010BDBM50045010(2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045025BDBM50045025(2-(2-Methoxy-phenyl)-3H-imidazo[4,5-c]pyridine; hy...)
Affinity DataIC50: 4.20E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045010BDBM50045010(2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[...)
Affinity DataIC50: 5.80E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045022BDBM50045022(2-[2-(3H-Imidazo[4,5-b]pyridin-2-yl)-phenoxy]-etha...)
Affinity DataIC50: 6.40E+4nMAssay Description:In vitro inhibition of PDE-V isolated from porcine pulmonary artery.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50000056BDBM50000056(CHEMBL286020 | 2-(4-Methanesulfinyl-2-methoxy-phen...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed