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Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50048913
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231248(CHEMBL97638)
Affinity DataEC50: >2.40E+5nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231288(CHEMBL329385)
Affinity DataEC50:  6.20E+3nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM87351(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
Affinity DataEC50:  720nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231250(CHEMBL319529)
Affinity DataEC50: >2.20E+5nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231251(CHEMBL319939)
Affinity DataEC50: >5.30E+5nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231252(CHEMBL419703)
Affinity DataEC50:  7.40E+4nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231253(CHEMBL328719)
Affinity DataEC50: >4.30E+5nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50045706(1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50:  1.70E+4nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231254(CHEMBL433389)
Affinity DataEC50:  1.70E+4nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231255(CHEMBL327663)
Affinity DataEC50:  5.20E+4nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataEC50:  810nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231256(CHEMBL94321)
Affinity DataEC50: >3.00E+5nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231257(CHEMBL96510)
Affinity DataEC50:  1.20E+3nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231258(CHEMBL441631)
Affinity DataEC50:  1.30E+4nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231259(CHEMBL97315)
Affinity DataEC50:  5.30E+4nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231260(CHEMBL96705)
Affinity DataEC50: >2.60E+5nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231261(CHEMBL94671)
Affinity DataEC50:  1.10E+5nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231262(CHEMBL96509)
Affinity DataEC50: >4.20E+5nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231263(CHEMBL15464 | CI-938)
Affinity DataEC50:  3.40E+5nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231264(CHEMBL97087)
Affinity DataEC50:  1.60E+4nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50045698(1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50:  7.60E+3nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231285(CHEMBL544553)
Affinity DataEC50: >1.40E+5nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231287(CHEMBL94506)
Affinity DataEC50:  1.60E+4nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50231249(CHEMBL47255)
Affinity DataEC50:  1.50E+5nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed