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Report error Found 195 Enz. Inhib. hit(s) with all data for entry = 50006402
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50048608(CHEMBL154488 | Indol-1-yl-pyridin-4-yl-amine)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50048589(CHEMBL152842 | Indol-1-yl-methyl-pyridin-4-yl-amin...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50048600(CHEMBL154541 | Ethyl-indol-1-yl-pyridin-4-yl-amine)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against [3H]idazoxan binding to Alpha-2 adrenergic receptor in rat cortex, in the presence of GPPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048600(CHEMBL154541 | Ethyl-indol-1-yl-pyridin-4-yl-amine)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against [3H]yohimbine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcetylcholinesterase(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  320nMAssay Description:Inhibitory activity against acetylcholinesterase in rat striatal preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  330nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048576(Butyl-indol-1-yl-pyridin-4-yl-amine | CHEMBL155109)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  460nMAssay Description:Inhibitory activity against [3H]oxotremorine-M binding to muscarinic receptors in rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  470nMAssay Description:Inhibitory activity against [3H]-idazoxan binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048610(CHEMBL435034 | Carbazol-9-yl-propyl-pyridin-4-yl-a...)
Affinity DataIC50:  500nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50048602(CHEMBL348034 | Indol-1-yl-prop-2-ynyl-pyridin-4-yl...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048608(CHEMBL154488 | Indol-1-yl-pyridin-4-yl-amine)
Affinity DataIC50:  510nMAssay Description:Inhibitory activity against [3H]WB-4101 binding to Alpha-1 adrenergic receptor in rat whole brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50048610(CHEMBL435034 | Carbazol-9-yl-propyl-pyridin-4-yl-a...)
Affinity DataIC50:  540nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048575((5-Methoxy-indol-1-yl)-propyl-pyridin-4-yl-amine |...)
Affinity DataIC50:  570nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048590(CHEMBL154319 | Indol-1-yl-isopropyl-pyridin-4-yl-a...)
Affinity DataIC50:  630nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50048576(Butyl-indol-1-yl-pyridin-4-yl-amine | CHEMBL155109)
Affinity DataIC50:  630nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M2(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  650nMAssay Description:Inhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)PMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50004665((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Affinity DataIC50:  660nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50454302(CHEMBL347199)
Affinity DataIC50:  670nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048602(CHEMBL348034 | Indol-1-yl-prop-2-ynyl-pyridin-4-yl...)
Affinity DataIC50:  680nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048611((3-Ethyl-indol-1-yl)-propyl-pyridin-4-yl-amine | C...)
Affinity DataIC50:  710nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048583(1-(Propyl-pyridin-4-yl-amino)-1H-indole-3-carbonit...)
Affinity DataIC50:  750nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  940nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048574(Allyl-indol-1-yl-pyridin-4-yl-amine | CHEMBL347336)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048589(CHEMBL152842 | Indol-1-yl-methyl-pyridin-4-yl-amin...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M2(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity of the compound against [3H]-N-methyl-scopalamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against [3H]-DHM binding to mu opioid receptor in rat whole brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048573((2-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine | ...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048589(CHEMBL152842 | Indol-1-yl-methyl-pyridin-4-yl-amin...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against [3H]WB-4101 binding to Alpha-1 adrenergic receptor in rat whole brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048587((3-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine | ...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory activity of the compound against [3H]-pirenzepine binding to muscarinic M1 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048579(CHEMBL345607 | Carbazol-9-yl-pyridin-4-yl-amine; c...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048599(CHEMBL346142 | Indazol-1-yl-propyl-pyridin-4-yl-am...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048609(CHEMBL345251 | Indol-1-yl-propyl-pyrimidin-4-yl-am...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048573((2-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine | ...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048576(Butyl-indol-1-yl-pyridin-4-yl-amine | CHEMBL155109)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048582((5-Bromo-indol-1-yl)-propyl-pyridin-4-yl-amine | C...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048584(1-(Propyl-pyridin-4-yl-amino)-1H-indole-3-carbalde...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048577((5-Chloro-indol-1-yl)-propyl-pyridin-4-yl-amine | ...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048611((3-Ethyl-indol-1-yl)-propyl-pyridin-4-yl-amine | C...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048584(1-(Propyl-pyridin-4-yl-amino)-1H-indole-3-carbalde...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048590(CHEMBL154319 | Indol-1-yl-isopropyl-pyridin-4-yl-a...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50048573((2-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine | ...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048577((5-Chloro-indol-1-yl)-propyl-pyridin-4-yl-amine | ...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048610(CHEMBL435034 | Carbazol-9-yl-propyl-pyridin-4-yl-a...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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