Compile Data Set for Download or QSAR
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Found 19 Enz. Inhib. hit(s) with all data for entry = 50006936
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Fibrinogen Receptor integrin alphaIIb-beta3 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [125I]fibrinogen binding to activated human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055906(3-{2-[(S)-3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-i...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055895(3-{2-[3-(2-Piperidin-4-yl-ethyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  630nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055900(3-{2-[(R)-3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-i...)
Affinity DataIC50:  860nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055894(2-(Butane-1-sulfonylamino)-3-{3-[4-(piperidin-4-yl...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055904(CHEMBL347490 | {3-[4-(2-Piperidin-4-yl-ethoxy)-phe...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055902(3-{2-[3-(3-Piperidin-4-yl-propyl)-4,5-dihydro-isox...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055905(3-{3-[4-(Piperidin-4-ylmethoxy)-phenyl]-4,5-dihydr...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055899(Benzyloxycarbonylamino-{3-[4-(2-piperidin-4-yl-eth...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055903(CHEMBL154203 | {3-[4-(Piperidin-4-ylmethoxy)-pheny...)
Affinity DataIC50:  3.66E+4nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055898(3-[4-(2-Piperidin-4-yl-ethoxy)-phenyl]-4,5-dihydro...)
Affinity DataIC50:  3.82E+4nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055901(3-{3-[4-(2-Piperidin-4-yl-ethoxy)-phenyl]-4,5-dihy...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-M/beta-2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of Mac-1 interaction with ICAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-M/beta-2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Mac-1 integrin (alphaM-beta2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of VLA-4 integrin alpha4-beta1 interaction with VCAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055897(3-[2-(3-Piperidin-4-ylmethyl-4,5-dihydro-isoxazol-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibition of interaction between HUVEC cells and fibronectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed