Compile Data Set for Download or QSAR
maximum 50k data
Found 50 Enz. Inhib. hit(s) with all data for entry = 50034961
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  60nMAssay Description:Inhibition of the dual specificity kinase MEK-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  70nMAssay Description:Inhibition of the dual specificity kinase MEK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  200nMAssay Description:AP-1 suppression activity using freshly prepared DMSO stockMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  300nMAssay Description:AP-1 suppression activity using one month old DMSO stockMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072154(2,3-Bis-[1-amino-1-(2-hydroxy-phenylsulfanyl)-meth...)
Affinity DataIC50:  300nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072163(2,3-Bis-[1-amino-1-(thiophen-2-ylsulfanyl)-meth-(Z...)
Affinity DataIC50:  300nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  300nMAssay Description:AP-1 suppression activity using one week old DMSO stockMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072154(2,3-Bis-[1-amino-1-(2-hydroxy-phenylsulfanyl)-meth...)
Affinity DataIC50:  400nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072166(2,3-Bis-[1-amino-1-(4-hydroxy-phenylsulfanyl)-meth...)
Affinity DataIC50:  400nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072151(2,3-Bis-[1-amino-1-(4-amino-phenylsulfanyl)-meth-(...)
Affinity DataIC50:  500nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  500nMAssay Description:AP-1 suppression activity using two months old DMSO stockMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  500nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072148(2,3-Bis-[3H-benzothiazol-(2Z)-ylidene]-succinonitr...)
Affinity DataIC50:  700nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072162(2,3-Bis-[1-amino-1-(2-chloro-phenylsulfanyl)-meth-...)
Affinity DataIC50:  900nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072164(2,3-Bis-[1-amino-1-phenylsulfanyl-meth-(Z)-ylidene...)
Affinity DataIC50:  900nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072156(2,3-Bis-[1-amino-1-(2-fluoro-phenylsulfanyl)-meth-...)
Affinity DataIC50:  900nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  1.00E+3nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072150(2,3-Bis-[1-amino-1-(2-bromo-phenylsulfanyl)-meth-(...)
Affinity DataIC50:  1.10E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072163(2,3-Bis-[1-amino-1-(thiophen-2-ylsulfanyl)-meth-(Z...)
Affinity DataIC50:  1.20E+3nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072144(2-Amino-5-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4...)
Affinity DataIC50:  1.40E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072157(2,3-Bis-[1-amino-1-(3-chloro-phenylsulfanyl)-meth-...)
Affinity DataIC50:  1.90E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072146(CHEMBL316635 | N-[3,4-Dicyano-5-(naphthalen-2-ylsu...)
Affinity DataIC50:  1.90E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072161(2,3-Bis-[1-amino-1-o-tolylsulfanyl-meth-(Z)-yliden...)
Affinity DataIC50:  2.00E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072160(2,5-Bis-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4-d...)
Affinity DataIC50:  2.10E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072158(2,3-Bis-[1-amino-1-(1-amino-naphthalen-2-ylsulfany...)
Affinity DataIC50:  2.10E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072152(2,3-Bis-[1-amino-1-(4-chloro-phenylsulfanyl)-meth-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of the dual specificity kinase MEK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072159(2,3-Bis-[1-amino-1-(2,6-dichloro-phenylsulfanyl)-m...)
Affinity DataIC50:  2.80E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072165(2-[1-Amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-yli...)
Affinity DataIC50:  3.20E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072155(2,3-Bis-[1-amino-1-(2-methoxy-phenylsulfanyl)-meth...)
Affinity DataIC50:  4.50E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072149(2,3-Bis-[1-amino-1-(3-amino-phenylsulfanyl)-meth-(...)
Affinity DataIC50:  4.80E+3nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072159(2,3-Bis-[1-amino-1-(2,6-dichloro-phenylsulfanyl)-m...)
Affinity DataIC50:  6.50E+3nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072162(2,3-Bis-[1-amino-1-(2-chloro-phenylsulfanyl)-meth-...)
Affinity DataIC50:  6.60E+3nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072156(2,3-Bis-[1-amino-1-(2-fluoro-phenylsulfanyl)-meth-...)
Affinity DataIC50:  7.60E+3nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072150(2,3-Bis-[1-amino-1-(2-bromo-phenylsulfanyl)-meth-(...)
Affinity DataIC50:  7.90E+3nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072146(CHEMBL316635 | N-[3,4-Dicyano-5-(naphthalen-2-ylsu...)
Affinity DataIC50:  8.00E+3nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072151(2,3-Bis-[1-amino-1-(4-amino-phenylsulfanyl)-meth-(...)
Affinity DataIC50:  1.05E+4nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072164(2,3-Bis-[1-amino-1-phenylsulfanyl-meth-(Z)-ylidene...)
Affinity DataIC50:  1.22E+4nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072161(2,3-Bis-[1-amino-1-o-tolylsulfanyl-meth-(Z)-yliden...)
Affinity DataIC50:  1.33E+4nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072145(2-Amino-5-(2-amino-phenylsulfanyl)-1H-pyrrole-3,4-...)
Affinity DataIC50:  1.35E+4nMAssay Description:Non-competitive inhibition of the dual specificity kinase MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072155(2,3-Bis-[1-amino-1-(2-methoxy-phenylsulfanyl)-meth...)
Affinity DataIC50:  1.65E+4nMAssay Description:Inhibition of the dual specificity kinase MEK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072149(2,3-Bis-[1-amino-1-(3-amino-phenylsulfanyl)-meth-(...)
Affinity DataIC50:  1.81E+4nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072157(2,3-Bis-[1-amino-1-(3-chloro-phenylsulfanyl)-meth-...)
Affinity DataIC50:  1.84E+4nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072165(2-[1-Amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-yli...)
Affinity DataIC50:  1.87E+4nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072152(2,3-Bis-[1-amino-1-(4-chloro-phenylsulfanyl)-meth-...)
Affinity DataIC50:  2.17E+4nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  2.48E+4nMAssay Description:AP-1 suppression activity using six months old DMSO stockMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072144(2-Amino-5-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4...)
Affinity DataIC50:  2.51E+4nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072145(2-Amino-5-(2-amino-phenylsulfanyl)-1H-pyrrole-3,4-...)
Affinity DataIC50:  2.62E+4nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072160(2,5-Bis-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4-d...)
Affinity DataIC50:  2.89E+4nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072148(2,3-Bis-[3H-benzothiazol-(2Z)-ylidene]-succinonitr...)
Affinity DataIC50:  4.25E+4nMAssay Description:Ability to antagonise AP-1 transcriptional activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed