Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 12262
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691368(US12065447, Compound ZB-R-54)
Affinity DataIC50: 0.100nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691367(US12065447, Compound ZB-R-53)
Affinity DataIC50: 0.110nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691358(US12065447, Compound ZB-R-39)
Affinity DataIC50: 0.170nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691376(US12065447, Compound ZB-R-84)
Affinity DataIC50: 0.190nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691370(US12065447, Compound ZB-R-68)
Affinity DataIC50: 0.200nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691378(US12065447, Compound ZB-R-87)
Affinity DataIC50: 0.200nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691364(US12065447, Compound ZB-R-50)
Affinity DataIC50: 0.260nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691374(US12065447, Compound ZB-R-81)
Affinity DataIC50: 0.290nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691375(US12065447, Compound ZB-R-82)
Affinity DataIC50: 0.300nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691373(US12065447, Compound ZB-R-80)
Affinity DataIC50: 0.310nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691359(US12065447, Compound ZB-R-42)
Affinity DataIC50: 0.320nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691372(US12065447, Compound ZB-R-78)
Affinity DataIC50: 0.350nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691363(US12065447, Compound ZB-R-47)
Affinity DataIC50: 0.390nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691366(US12065447, Compound ZB-R-52)
Affinity DataIC50: 0.420nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691369(US12065447, Compound ZB-R-55)
Affinity DataIC50: 0.5nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691365(US12065447, Compound ZB-R-51)
Affinity DataIC50: 0.5nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691380(US12065447, Compound ZB-R-20)
Affinity DataIC50: 0.5nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691371(US12065447, Compound ZB-R-76)
Affinity DataIC50: 0.540nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691381(US12065447, Compound ZB-R-24)
Affinity DataIC50: 1nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691377(US12065447, Compound ZB-R-85)
Affinity DataIC50: 1.09nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691379(US12065447, Compound ZB-R-89)
Affinity DataIC50: 1.70nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691382(US12065447, Compound ZB-R-25)
Affinity DataIC50: 2nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM50233225(CHEMBL4071864 | US12065447, Compound GSK2982772 | ...)
Affinity DataIC50: 2.30nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691360(US12065447, Compound ZB-R-44)
Affinity DataIC50: 4.08nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691362(US12065447, Compound ZB-R-46)
Affinity DataIC50: 5.39nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM691361(US12065447, Compound ZB-R-45)
Affinity DataIC50: 8.13nMAssay Description:TNFalpha induced U937 cell programmed necroptosis system was used to screen for compounds with RIP 1 kinase inhibitory activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent