Compile Data Set for Download or QSAR
Report error Found 277 Enz. Inhib. hit(s) with all data for entry = 12324
TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695597BDBM695597(US12084420, Compound 151 | N-(1$#8243;-(3-((2-azas...)
Affinity DataKi:  0.120nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695618BDBM695618(US12084420, Compound 182 | N-(1-methylcyclobutyl)-...)
Affinity DataKi:  0.260nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695639BDBM695639(US12084420, Compound 223 | N-(bicyclo[1.1.1]pentan...)
Affinity DataKi:  0.260nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695645BDBM695645(US12084420, Compound 229 | N-(1$#8243;-(3- (cyclop...)
Affinity DataKi:  0.290nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695559BDBM695559(US12084420, Compound 24b)
Affinity DataKi:  0.290nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695595BDBM695595(US12084420, Compound 148 | N-(tert-butyl)-3-(5$#82...)
Affinity DataKi:  0.290nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695669BDBM695669(US12084420, Compound 262 | N-(tert-butyl)-4-(5$#82...)
Affinity DataKi:  0.310nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695588BDBM695588(US12084420, Compound 134 | N-(tert-butyl)-3-(5$#82...)
Affinity DataKi:  0.340nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695692BDBM695692(US12084420, Compound 297 | N-(tert-butyl)-2-methox...)
Affinity DataKi:  0.380nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695693BDBM695693(US12084420, Compound 298 | N-(tert-butyl)-2-hydrox...)
Affinity DataKi:  0.380nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695650BDBM695650(US12084420, Compound 237 | N-(1$#8243;-(3-((6,6-di...)
Affinity DataKi:  0.440nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695729BDBM695729(US12084420, Compound 333a)
Affinity DataKi:  0.470nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695780BDBM695780(US12084420, Compound 140a)
Affinity DataKi:  0.5nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695558BDBM695558(US12084420, Compound 24a)
Affinity DataKi:  0.540nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695602BDBM695602(US12084420, Compound 160 | N-(tert-butyl)-3-(5$#82...)
Affinity DataKi:  0.540nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695555BDBM695555(US12084420, Compound 22 | N-(tert-butyl)-3-(5$#824...)
Affinity DataKi:  0.550nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695719BDBM695719(US12084420, Compound 320 | N-(1$#8243;-(3-((1-oxa-...)
Affinity DataKi:  0.570nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695623BDBM695623(US12084420, Compound 192 | N-(3,3-difluorocyclobut...)
Affinity DataKi:  0.640nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695730BDBM695730(US12084420, Compound 333b)
Affinity DataKi:  0.770nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695601BDBM695601(US12084420, Compound 159 | N-(tert-butyl)-2-fluoro...)
Affinity DataKi:  0.830nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695665BDBM695665(US12084420, Compound 257 | N-(1$#8243;-(3-((3,3-di...)
Affinity DataKi:  0.960nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695651BDBM695651(US12084420, Compound (R)-239)
Affinity DataKi:  1.40nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695781BDBM695781(US12084420, Compound 140b)
Affinity DataKi:  1.40nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695552BDBM695552(US12084420, Compound 19 | N-(1'-(3-((4,4-difluorop...)
Affinity DataKi:  1.80nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695603BDBM695603(US12084420, Compound 162a)
Affinity DataKi:  1.90nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695599BDBM695599(US12084420, Compound 155 | N-(1$#8243;-(3- (cyclop...)
Affinity DataKi:  2nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695769BDBM695769(US12084420, Compound 368b | US12084420, Compound 3...)
Affinity DataIC50: 3nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695755BDBM695755(US12084420, Compound 352b)
Affinity DataKi:  3.10nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695721BDBM695721(US12084420, Compound 322 | N-(1$#8243;-(3-((3,3- d...)
Affinity DataKi:  3.30nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695755BDBM695755(US12084420, Compound 352b)
Affinity DataIC50: 3.30nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695700BDBM695700(US12084420, Compound 305a)
Affinity DataKi:  3.5nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695769BDBM695769(US12084420, Compound 368b | US12084420, Compound 3...)
Affinity DataIC50: 3.5nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695701BDBM695701(US12084420, Compound 305b)
Affinity DataKi:  3.70nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695754BDBM695754(US12084420, Compound 352a)
Affinity DataKi:  3.70nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695767BDBM695767(US12084420, Compound 367b | US12084420, Compound 3...)
Affinity DataIC50: 3.90nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695608BDBM695608(US12084420, Compound 165b | US12084420, Compound 1...)
Affinity DataKi:  3.90nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695673BDBM695673(US12084420, Compound 269 | N-(tert-butyl)-5-(5$#82...)
Affinity DataKi:  4nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695754BDBM695754(US12084420, Compound 352a)
Affinity DataIC50: 4nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695608BDBM695608(US12084420, Compound 165b | US12084420, Compound 1...)
Affinity DataKi:  4.20nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695644BDBM695644(US12084420, Compound 228 | N-(1$#8243;-(3-((2-azas...)
Affinity DataIC50: 4.60nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695767BDBM695767(US12084420, Compound 367b | US12084420, Compound 3...)
Affinity DataIC50: 4.80nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695622BDBM695622(US12084420, Compound 190 | N-(3-methylenecyclobuty...)
Affinity DataIC50: 4.80nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695753BDBM695753(US12084420, Compound 352 | N-(1$#8243;-(5- (cyclop...)
Affinity DataIC50: 5nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695765BDBM695765(US12084420, Compound 364 | N-(1$#8243;-(4- (cyclop...)
Affinity DataIC50: 5.10nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695705BDBM695705(US12084420, Compound 311 | N-(bicyclo[1.1.1]pentan...)
Affinity DataIC50: 5.20nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695613BDBM695613(US12084420, Compound 172 | N-(cyclopent-3-en-1-yl)...)
Affinity DataIC50: 5.5nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695611BDBM695611(US12084420, Compound 168 | N-cyclobutyl-3-(5$#8243...)
Affinity DataIC50: 5.5nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695615BDBM695615(US12084420, Compound 176 | N-cyclopentyl-3-(5$#824...)
Affinity DataIC50: 5.60nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695688BDBM695688(US12084420, Compound 291 | N-cyclobutyl-4-(5$#8243...)
Affinity DataIC50: 5.80nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 695751BDBM695751(US12084420, Compound 351a)
Affinity DataKi:  5.80nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

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