Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 12382
LigandPNGBDBM699503(US12110278, Compound 15)
Affinity DataKd:  180nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM699503(US12110278, Compound 15)
Affinity DataKd:  200nMAssay Description:MST measurements were performed with a Monolith NT.115Pico device (NanoTemper Technologies). JH2 domain protein (triple mutant W659A, W777A, F794H, o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

LigandPNGBDBM699503(US12110278, Compound 15)
Affinity DataKd:  230nMAssay Description:MST measurements were performed with a Monolith NT.115Pico device (NanoTemper Technologies). JH2 domain protein (triple mutant W659A, W777A, F794H, o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514907(CHEMBL4449644 | US12110278, Compound 12)
Affinity DataKd:  290nMAssay Description:MST measurements were performed with a Monolith NT.115Pico device (NanoTemper Technologies). JH2 domain protein (triple mutant W659A, W777A, F794H, o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514902(CHEMBL4476380 | US12110278, Compound 10)
Affinity DataKd:  310nMAssay Description:MST measurements were performed with a Monolith NT.115Pico device (NanoTemper Technologies). JH2 domain protein (triple mutant W659A, W777A, F794H, o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514907(CHEMBL4449644 | US12110278, Compound 12)
Affinity DataKd:  346nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514907(CHEMBL4449644 | US12110278, Compound 12)
Affinity DataKd:  350nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM699503(US12110278, Compound 15)
Affinity DataKd:  370nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM699503(US12110278, Compound 15)
Affinity DataKd:  374nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

LigandPNGBDBM50514902(CHEMBL4476380 | US12110278, Compound 10)
Affinity DataKd:  400nMAssay Description:MST measurements were performed with a Monolith NT.115Pico device (NanoTemper Technologies). JH2 domain protein (triple mutant W659A, W777A, F794H, o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514907(CHEMBL4449644 | US12110278, Compound 12)
Affinity DataKd:  430nMAssay Description:MST measurements were performed with a Monolith NT.115Pico device (NanoTemper Technologies). JH2 domain protein (triple mutant W659A, W777A, F794H, o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514910(CHEMBL4440610 | US12110278, Compound 13)
Affinity DataKd:  439nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  456nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  460nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514907(CHEMBL4449644 | US12110278, Compound 12)
Affinity DataKd:  480nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  490nMAssay Description:MST measurements were performed with a Monolith NT.115Pico device (NanoTemper Technologies). JH2 domain protein (triple mutant W659A, W777A, F794H, o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50514902(CHEMBL4476380 | US12110278, Compound 10)
Affinity DataKd:  540nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514902(CHEMBL4476380 | US12110278, Compound 10)
Affinity DataKd:  570nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514902(CHEMBL4476380 | US12110278, Compound 10)
Affinity DataKd:  571nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  600nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514908(CHEMBL4539227 | US12110278, Compound 9)
Affinity DataKd:  643nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Yale University

US Patent
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  670nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  820nMAssay Description:MST measurements were performed with a Monolith NT.115Pico device (NanoTemper Technologies). JH2 domain protein (triple mutant W659A, W777A, F794H, o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514904(CHEMBL4519945 | US12110278, Compound 8)
Affinity DataKd:  1.90E+3nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514906(CHEMBL4437716 | US12110278, Compound 11)
Affinity DataKd:  4.00E+3nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514903(CHEMBL4475907 | US12110278, Compound 4)
Affinity DataKd:  4.70E+3nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Yale University

US Patent
LigandPNGBDBM699503(US12110278, Compound 15)
Affinity DataKd:  6.00E+3nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Yale University

US Patent
LigandPNGBDBM50514907(CHEMBL4449644 | US12110278, Compound 12)
Affinity DataKd:  6.60E+3nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514911(CHEMBL4560164 | US12110278, Compound 14)
Affinity DataKd:  7.00E+3nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514905(CHEMBL4453849 | US12110278, Compound 7)
Affinity DataKd:  1.23E+4nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM6875(4-({5-amino-1-[(2,6-difluorophenyl)methyl]-1H-1,2,...)
Affinity DataKd:  1.67E+4nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514900(CHEMBL4455581 | US12110278, Compound 6)
Affinity DataKd:  3.05E+4nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Yale University

US Patent
LigandPNGBDBM50514902(CHEMBL4476380 | US12110278, Compound 10)
Affinity DataKd:  4.23E+4nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514909(CHEMBL4582077 | US12110278, Compound 5)
Affinity DataKd:  4.78E+4nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent