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Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 12412
TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM701245(US12122771, Compound 15)
Affinity DataKi:  1.13nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM701207(US12122771, Compound 7)
Affinity DataKi:  1.14nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  2.21nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataKi:  4.85nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM701247(US12122771, Compound 19)
Affinity DataKi:  5.89nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataKi:  9.85nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618104(CHEMBL5425920 | US12122771, Compound 2)
Affinity DataKi:  21.2nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataKi:  22nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618113(CHEMBL5394387 | US12122771, Compound 9)
Affinity DataKi:  26nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618115(CHEMBL5399689 | US12122771, Compound 16)
Affinity DataKi:  54.7nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataKi:  58.5nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataKi:  104nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618104(CHEMBL5425920 | US12122771, Compound 2)
Affinity DataKi:  205nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM701207(US12122771, Compound 7)
Affinity DataKi:  288nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataKi:  408nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618113(CHEMBL5394387 | US12122771, Compound 9)
Affinity DataKi:  773nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM701207(US12122771, Compound 7)
Affinity DataKi:  777nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataKi:  830nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618104(CHEMBL5425920 | US12122771, Compound 2)
Affinity DataKi:  1.05E+3nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  1.15E+3nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  2.93E+3nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataKi:  4.86E+3nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618115(CHEMBL5399689 | US12122771, Compound 16)
Affinity DataKi:  6.89E+3nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618115(CHEMBL5399689 | US12122771, Compound 16)
Affinity DataKi:  1.18E+4nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM701247(US12122771, Compound 19)
Affinity DataKi:  1.23E+4nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618113(CHEMBL5394387 | US12122771, Compound 9)
Affinity DataKi:  1.33E+4nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM701247(US12122771, Compound 19)
Affinity DataKi:  1.67E+4nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataKi:  1.74E+4nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM701245(US12122771, Compound 15)
Affinity DataKi:  1.80E+4nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM701245(US12122771, Compound 15)
Affinity DataKi:  3.71E+4nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent