Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 12427
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701918(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl)-3,6-d...)
Affinity DataIC50: 0.0600nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702009(6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-(methoxy...)
Affinity DataIC50: 0.0600nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701996(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl-d2)-3,...)
Affinity DataIC50: 0.0700nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701995(4-(6-(6-((6-methoxypyridin-3-yl)methyl-d2)-3,6-dia...)
Affinity DataIC50: 0.110nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701994(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl)-3,6-d...)
Affinity DataIC50: 0.120nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702007(6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxyp...)
Affinity DataIC50: 0.150nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701992(4-(6-(6-((6-methoxypyridin-3-yl)methyl-d2)-3,6-dia...)
Affinity DataIC50: 0.160nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701992(4-(6-(6-((6-methoxypyridin-3-yl)methyl-d2)-3,6-dia...)
Affinity DataIC50: 0.160nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701918(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl)-3,6-d...)
Affinity DataIC50: 0.170nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702008(6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-(methoxy...)
Affinity DataIC50: 0.170nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701993(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl-d2)-3,...)
Affinity DataIC50: 0.170nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701997(4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazab...)
Affinity DataIC50: 0.180nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701997(4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazab...)
Affinity DataIC50: 0.210nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702006(4-(5-(6-((6-(methoxy-d3)pyridin-3-yl)methyl-d2)-3,...)
Affinity DataIC50: 0.230nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701995(4-(6-(6-((6-methoxypyridin-3-yl)methyl-d2)-3,6-dia...)
Affinity DataIC50: 0.230nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702009(6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-(methoxy...)
Affinity DataIC50: 0.270nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701993(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl-d2)-3,...)
Affinity DataIC50: 0.290nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701994(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl)-3,6-d...)
Affinity DataIC50: 0.330nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702004(4-(5-(6-((6-methoxypyridin-3-yl)methyl-d2)-3,6-dia...)
Affinity DataIC50: 0.360nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701996(4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl-d2)-3,...)
Affinity DataIC50: 0.360nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702005(4-(5-(6-((6-(methoxy-d3)pyridin-3-yl)methyl)-3,6-d...)
Affinity DataIC50: 0.370nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702007(6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxyp...)
Affinity DataIC50: 3.20nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702008(6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-(methoxy...)
Affinity DataIC50: 3.25nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702005(4-(5-(6-((6-(methoxy-d3)pyridin-3-yl)methyl)-3,6-d...)
Affinity DataIC50: 4.30nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702006(4-(5-(6-((6-(methoxy-d3)pyridin-3-yl)methyl-d2)-3,...)
Affinity DataIC50: 4.91nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702004(4-(5-(6-((6-methoxypyridin-3-yl)methyl-d2)-3,6-dia...)
Affinity DataIC50: 7.32nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent