Compile Data Set for Download or QSAR
Report error Found 234 Enz. Inhib. hit(s) with all data for entry = 12536
TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708012BDBM708012(2-(1-(3- chlorobenzoyl) piperidin-3-yl)- 5-hydroxy...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708076BDBM708076(2-(cyclohexyloxy)-5- hydroxy-N-(isoxazol-4-yl)- 1-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708075BDBM708075(5-hydroxy-N-(isoxazol-4- yl)-1-methyl-6-oxo-2- phe...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708010BDBM708010(5-hydroxy-N- (isoxazol-4-yl)-1- methyl-6-oxo-2-(1-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708042BDBM708042((S)-5-hydroxy-N- (isoxazol-4-yl)-1- methyl-6-oxo-2...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707977BDBM707977(2-(3-bromophenyl)-5- hydroxy-N-(isoxazol-4- yl)-1-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708041BDBM708041((R)-5-hydroxy-N- (isoxazol-4-yl)-1- methyl-6-oxo-2...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708073BDBM708073((R)-2-(3- carbamoylpyrrolidin-1-yl)- 5-hydroxy-N-(...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708080BDBM708080((S)-2-(2-(2-chlorophenyl)-4- (pyridin-2-yl)piperaz...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708080BDBM708080((S)-2-(2-(2-chlorophenyl)-4- (pyridin-2-yl)piperaz...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708079BDBM708079((R)-2-(2-(2- chlorophenyl)pyrrolidin-1- yl)-5-hydr...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707982BDBM707982(2-(3-bromo-2-(2-hydroxyethoxy)phenyl)-5-hydroxy-N-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707982BDBM707982(2-(3-bromo-2-(2-hydroxyethoxy)phenyl)-5-hydroxy-N-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708045BDBM708045(2-((3S,6S)-1-(3,4- dichlorobenzoyl)-6- methylpiper...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707972BDBM707972(2-(3-bromo-2- methylphenyl)-5- hydroxy-N-(isoxazol...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708035BDBM708035(2-(5-bromo-2-(2- hydroxyethoxy) phenyl)-5-hydroxy-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708066BDBM708066((S)-5-hydroxy-N-(isoxazol- 4-yl)-1-methyl-6-oxo-2-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708065BDBM708065((R)-5-hydroxy-N-(isoxazol- 4-yl)-1-methyl-6-oxo-2-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708040BDBM708040(2-(3-bromo-2-(2- hydroxyethyl)phenyl)- 5-hydroxy-N...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708070BDBM708070((R)-5-hydroxy-N-(isoxazol- 4-yl)-1-methyl-6-oxo-2-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708069BDBM708069((S)-5-hydroxy-N-(isoxazol- 4-yl)-1-methyl-6-oxo-2-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708064BDBM708064((R)-5-hydroxy-2-(2-(2- hydroxyethyl)piperidin-1- y...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707968BDBM707968(2-(3-bromo-5-methylphenyl)-5-hydroxy-N-(isoxazol-4...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708084BDBM708084(1-((2-((R)-1-(3,4-dichlorobenzoyl)piperidin-3-yl)-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708084BDBM708084(1-((2-((R)-1-(3,4-dichlorobenzoyl)piperidin-3-yl)-...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708049BDBM708049((S)-2-(1-(3-chloro-4- fluorobenzoyl)piperidin-3-yl...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708081BDBM708081((R)-2-(4-acetyl-2-(2- chlorophenyl)piperazin-1- yl...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708081BDBM708081((R)-2-(4-acetyl-2-(2- chlorophenyl)piperazin-1- yl...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708056BDBM708056((S)-2-(1-(3,4- dichlorobenzoyl)piperidin-3-yl)-5- ...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708056BDBM708056((S)-2-(1-(3,4- dichlorobenzoyl)piperidin-3-yl)-5- ...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708022BDBM708022(5-hydroxy-N- (isoxazol-4-yl)-1- methyl-2-(3-methyl...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707980BDBM707980(tert-butyl 3-(5-hydroxy- 4-(isoxazol-4- ylcarbamoy...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707978BDBM707978(2-(4-bromophenyl)-5- hydroxy-N-(isoxazol-4- yl)-1-...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707977BDBM707977(2-(3-bromophenyl)-5- hydroxy-N-(isoxazol-4- yl)-1-...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707983BDBM707983(tert-butyl 3-(5- hydroxy-4-(isoxazol- 4-ylcarbamoy...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707981BDBM707981(tert-butyl 2-(5-hydroxy- 4-(isoxazol-4- ylcarbamoy...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707981BDBM707981(tert-butyl 2-(5-hydroxy- 4-(isoxazol-4- ylcarbamoy...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707972BDBM707972(2-(3-bromo-2- methylphenyl)-5- hydroxy-N-(isoxazol...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707971BDBM707971(2-(5-bromo-2- methylphenyl)-5- hydroxy-N-(isoxazol...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707971BDBM707971(2-(5-bromo-2- methylphenyl)-5- hydroxy-N-(isoxazol...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707970BDBM707970(2-cyclopropyl-5- hydroxy-N-(isoxazol- 4-yl)-1-meth...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707969BDBM707969(2-cyclobutyl-5- hydroxy-N-(isoxazol- 4-yl)-1-methy...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707976BDBM707976(2-(2-bromophenyl)-5- hydroxy-N-(isoxazol-4- yl)-1-...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707975BDBM707975(US12172990, Example 8)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707974BDBM707974(benzyl (1-(5-hydroxy- 4-(isoxazol-4- ylcarbamoyl)-...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707973BDBM707973(2-benzyl-5-hydroxy- N-(isoxazol-4-yl)-1- methyl-6-...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707995BDBM707995(5-hydroxy-N-(isoxazol-4-yl)-1-methyl-6-oxo-2-(pipe...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 708000BDBM708000(5-hydroxy-N- (isoxazol-4-yl)-1- methyl-2-(3-methyl...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707999BDBM707999(5-hydroxy-N- (isoxazol-4-yl)-1- methyl-2-(3-methyl...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 707999BDBM707999(5-hydroxy-N- (isoxazol-4-yl)-1- methyl-2-(3-methyl...)
Affinity DataIC50: 55nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

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