Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 12595
TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712709BDBM712709((R)-8-(3-chloro-5-fluorophenoxy)-N-((1R,5S,8s)-3-(...)
Affinity DataIC50: 6.30nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50561738BDBM50561738(CHEMBL4793969 | US12195470, Example 49)
Affinity DataIC50: 6.60nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50561734BDBM50561734(CHEMBL4782495 | US12195470, Example 3)
Affinity DataIC50: 8.10nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50561739BDBM50561739(CHEMBL4741478 | US12195470, Example 55)
Affinity DataIC50: 8.10nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50561736BDBM50561736(CHEMBL4750933 | US12195470, Example 41)
Affinity DataIC50: 9.90nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50561737BDBM50561737(CHEMBL4788632 | US12195470, Example 45)
Affinity DataIC50: 10.3nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712754BDBM712754((R)—N-((1R,5S,8s)-3-(6-methylpyrimidin-4-yl)-3-aza...)
Affinity DataIC50: 10.5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712711BDBM712711((R)-8-(3,5-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 10.6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712750BDBM712750((R)-8-(3,4-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 11.3nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712713BDBM712713((R)—N-((1R,5S,8s)-3-(6-methoxypyridazin-4-yl)-3-az...)
Affinity DataIC50: 11.3nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712708BDBM712708((R)—N-((1R,5S,8s)-3-(6-methoxypyridazin-4-yl)-3-az...)
Affinity DataIC50: 11.4nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712745BDBM712745((R)-7-(3-chloro-5-fluorophenoxy)-N-((1R,5S,8s)-3-(...)
Affinity DataIC50: 11.7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712722BDBM712722((R)-8-(3-chlorophenoxy)-N-((1R,5S,8s)-3-(6-methoxy...)
Affinity DataIC50: 11.9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712741BDBM712741((R)-8-(3,5-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 12.4nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712703BDBM712703((R)-7-(3,5-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 12.8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712758BDBM712758((R)—N-((1R,5S,8s)-3-(6-methylpyrimidin-4-yl)-3-aza...)
Affinity DataIC50: 13.6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712760BDBM712760((R)-9-(3-chloro-5-fluorophenoxy)-N-((1R,5S,8s)-3-(...)
Affinity DataIC50: 13.8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712730BDBM712730((R)-8-(2-chlorophenoxy)-N-((1R,5S,8s)-3-(6-methylp...)
Affinity DataIC50: 13.8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712737BDBM712737((R)-7-(3,5-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 15.6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712724BDBM712724((R)-8-(2-chlorophenoxy)-N-((1R,5S,8s)-3-(6-methoxy...)
Affinity DataIC50: 15.7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712734BDBM712734((R)-7-(3,5-dichlorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 16nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712726BDBM712726((R)-7-(4-chlorophenoxy)-N-((1R,5S,8s)-3-(6-methylp...)
Affinity DataIC50: 16.5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712732BDBM712732((R)-8-(2,3-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 17.1nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712728BDBM712728((R)-7-(3-chlorophenoxy)-N-((1R,5S,8s)-3-(6-methylp...)
Affinity DataIC50: 17.5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712749BDBM712749((R)—N-((1R,5S,8s)-3-(6-methylpyrimidin-4-yl)-3-aza...)
Affinity DataIC50: 17.7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712715BDBM712715((R)-8-(3-chloro-5-fluorophenoxy)-N-((1R,5S,8s)-3-(...)
Affinity DataIC50: 19.9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712748BDBM712748((R)-8-(3,5-dichlorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 20nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712736BDBM712736((R)-8-(2,4-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 21.6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712735BDBM712735((R)-7-(3,5-dichlorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 22.4nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712740BDBM712740((R)-8-(3-chlorophenoxy)-N-((1R,5S,8s)-3-(6-methylp...)
Affinity DataIC50: 27.5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712746BDBM712746((R)-7-(3-chloro-5-fluorophenoxy)-N-((1R,5S,8s)-3-(...)
Affinity DataIC50: 27.7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712744BDBM712744((R)-8-(4-chlorophenoxy)-N-((1R,5S,8s)-3-(6-methylp...)
Affinity DataIC50: 28.2nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712753BDBM712753((R)-8-(3-chloro-5-fluorophenoxy)-N-((1R,5S,8s)-3-(...)
Affinity DataIC50: 29.5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712720BDBM712720((R)-8-(2,3-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 31.8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712731BDBM712731((R)-8-(2-chlorophenoxy)-N-((1R,5S,8s)-3-(6-methylp...)
Affinity DataIC50: 33.5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712725BDBM712725((R)-8-(2-chlorophenoxy)-N-((1R,5S,8s)-3-(6-methoxy...)
Affinity DataIC50: 33.8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712742BDBM712742((R)-8-(3,5-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 34nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50561735BDBM50561735(CHEMBL4793879 | US12195470, Example 8)
Affinity DataIC50: 34.1nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712761BDBM712761((R)-9-(3-chloro-5-fluorophenoxy)-N-((1R,5S,8s)-3-(...)
Affinity DataIC50: 34.7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712717BDBM712717((R)-8-(3,5-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 35.7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712719BDBM712719((R)-8-(2,4-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 36.8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712712BDBM712712((R)-8-(3,5-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 39.3nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712707BDBM712707((R)-7-(3-chloro-5-fluorophenoxy)-N-((1R,5S,8s)-3-(...)
Affinity DataIC50: 41.3nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712751BDBM712751((R)-8-(3,4-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 41.3nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712756BDBM712756((R)-9-(4-fluorophenoxy)-N-((1R,5S,8s)-3-(6-methylp...)
Affinity DataIC50: 42.8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712755BDBM712755((R)—N-((1R,5S,8s)-3-(6-methylpyrimidin-4-yl)-3-aza...)
Affinity DataIC50: 43.2nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712718BDBM712718((R)—N-((1R,5S,8s)-3-(6-methylpyridazin-4-yl)-3-aza...)
Affinity DataIC50: 49.7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712729BDBM712729((R)-7-(3-chlorophenoxy)-N-((1R,5S,8s)-3-(6-methylp...)
Affinity DataIC50: 51.9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712733BDBM712733((R)-8-(2,3-difluorophenoxy)-N-((1R,5S,8s)-3-(6-met...)
Affinity DataIC50: 53.6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 712723BDBM712723((R)-8-(3-chlorophenoxy)-N-((1R,5S,8s)-3-(6-methoxy...)
Affinity DataIC50: 57.5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

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