Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 12596
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712739(US12195473, Compound 1-2)
Affinity DataIC50: 1.41nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712763(US12195473, Compound 6)
Affinity DataIC50: 1.51nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712781(US12195473, Compound A)
Affinity DataIC50: 1.69nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712773(US12195473, Compound 12-2)
Affinity DataIC50: 2.01nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712770(US12195473, Compound 11-2)
Affinity DataIC50: 2.11nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712766(US12195473, Compound 9)
Affinity DataIC50: 2.30nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712775(US12195473, Compound 13-1)
Affinity DataIC50: 2.73nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM50579593(CHEMBL4860030 | US12195473, Amgen 6.3)
Affinity DataIC50: 2.77nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712706(US12195473, Compound 1)
Affinity DataIC50: 3.06nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712752(US12195473, Compound 4)
Affinity DataIC50: 3.48nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712777(US12195473, Compound 14)
Affinity DataIC50: 3.56nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712747(US12195473, Compound 3)
Affinity DataIC50: 3.67nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712771(US12195473, Compound 12)
Affinity DataIC50: 3.85nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712768(US12195473, Compound 10-2)
Affinity DataIC50: 4.16nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM50579592(CHEMBL4876344 | US12195473, Amgen 6)
Affinity DataIC50: 4.40nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712762(US12195473, Compound 5)
Affinity DataIC50: 5.97nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712774(US12195473, Compound 13)
Affinity DataIC50: 6.63nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712743(US12195473, Compound 2)
Affinity DataIC50: 6.66nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712765(US12195473, Compound 8)
Affinity DataIC50: 6.68nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712778(US12195473, Compound 15-1)
Affinity DataIC50: 6.87nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712784(US12195473, Amgen 7.3)
Affinity DataIC50: 10.5nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712776(US12195473, Compound 13-2)
Affinity DataIC50: 11.5nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712710(US12195473, Compound 1-1)
Affinity DataIC50: 14.1nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712764(US12195473, Compound 7)
Affinity DataIC50: 14.9nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712772(US12195473, Compound 12-1)
Affinity DataIC50: 16nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712769(US12195473, Compound 11-1)
Affinity DataIC50: 29.6nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712767(US12195473, Compound 10-1)
Affinity DataIC50: 43.9nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712779(US12195473, Compound 15-2)
Affinity DataIC50: 83.9nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent