Compile Data Set for Download or QSAR
Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 13034
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753568BDBM753568(4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazab...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 677919BDBM677919(US20240174674, Compound 235 | US12338253, Compound...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753566BDBM753566(6-(2,2-difluoroethoxy)-4-(6-(6-((6-methoxypyridin-...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753528BDBM753528(6-(2-fluoroethoxy)-4-(6-(6-((6-methoxypyridin-3-yl...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753524BDBM753524(6-(2-(difluoromethoxy)ethoxy)-4-(6-(6-((6-methoxyp...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753573BDBM753573((3-(5-(6-(2-fluoroethoxy)-1H-pyrazolo[3',4':3,4]py...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753566BDBM753566(6-(2,2-difluoroethoxy)-4-(6-(6-((6-methoxypyridin-...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753528BDBM753528(6-(2-fluoroethoxy)-4-(6-(6-((6-methoxypyridin-3-yl...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753524BDBM753524(6-(2-(difluoromethoxy)ethoxy)-4-(6-(6-((6-methoxyp...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753517BDBM753517(6-(3-fluoropropoxy)-4-(6-(6-((6-methoxypyridin-3-y...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753511BDBM753511(6-(2-methoxyethoxy)-4-(6-(6-((6-methoxypyridin-3-y...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753572BDBM753572((2S)-2-(((4-(6-((6-methoxypyridin-3-yl)methyl)-3,6...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753571BDBM753571(6-(2-fluoroethoxy)-4-(5-(6-((6-methoxypyridin-3-yl...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753517BDBM753517(6-(3-fluoropropoxy)-4-(6-(6-((6-methoxypyridin-3-y...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 677953BDBM677953(US20240174674, Compound 297 | US12338253, Compound...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753511BDBM753511(6-(2-methoxyethoxy)-4-(6-(6-((6-methoxypyridin-3-y...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753568BDBM753568(4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazab...)
Affinity DataIC50: 0.200nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 677919BDBM677919(US20240174674, Compound 235 | US12338253, Compound...)
Affinity DataIC50: 0.200nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 677953BDBM677953(US20240174674, Compound 297 | US12338253, Compound...)
Affinity DataIC50: 0.200nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753569BDBM753569(6-isobutoxy-4-(6-(6-((6-methoxypyridin-3-yl)methyl...)
Affinity DataIC50: 0.300nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753569BDBM753569(6-isobutoxy-4-(6-(6-((6-methoxypyridin-3-yl)methyl...)
Affinity DataIC50: 0.400nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753584BDBM753584((R)-1-(4-(5-(6-(2-fluoroethoxy)-1H-pyrazolo[3',4':...)
Affinity DataIC50: 0.600nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753528BDBM753528(6-(2-fluoroethoxy)-4-(6-(6-((6-methoxypyridin-3-yl...)
Affinity DataIC50: 1nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753583BDBM753583((R)-1-(4-(5-(6-(2-fluoroethoxy)-1H-pyrazolo[3',4':...)
Affinity DataIC50: 1.60nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753585BDBM753585((4-(5-(6-(2-fluoroethoxy)-1H-pyrazolo[3',4':3,4]py...)
Affinity DataIC50: 1.70nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 677919BDBM677919(US20240174674, Compound 235 | US12338253, Compound...)
Affinity DataIC50: 1.70nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 677953BDBM677953(US20240174674, Compound 297 | US12338253, Compound...)
Affinity DataIC50: 1.90nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753588BDBM753588(2-((4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-di...)
Affinity DataIC50: 2.10nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753579BDBM753579(6-(2-chloroethoxy)-4-(6-(6-((6-methoxypyridin-3-yl...)
Affinity DataIC50: 2.20nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753566BDBM753566(6-(2,2-difluoroethoxy)-4-(6-(6-((6-methoxypyridin-...)
Affinity DataIC50: 2.30nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753586BDBM753586(6-methoxy-4-(5-(6-((6-methoxypyridin-3-yl)methyl)-...)
Affinity DataIC50: 2.30nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753511BDBM753511(6-(2-methoxyethoxy)-4-(6-(6-((6-methoxypyridin-3-y...)
Affinity DataIC50: 2.70nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753571BDBM753571(6-(2-fluoroethoxy)-4-(5-(6-((6-methoxypyridin-3-yl...)
Affinity DataIC50: 2.90nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753568BDBM753568(4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazab...)
Affinity DataIC50: 2.90nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753481BDBM753481(6-(2-methoxyethoxy)-4-(6-(6-((6-methoxypyridin-3-y...)
Affinity DataIC50: 2.90nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753578BDBM753578(6-(4-fluorobutoxy)-4-(6-(6-((6-methoxypyridin-3-yl...)
Affinity DataIC50: 3.10nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753576BDBM753576(2-((4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-di...)
Affinity DataIC50: 3.80nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753517BDBM753517(6-(3-fluoropropoxy)-4-(6-(6-((6-methoxypyridin-3-y...)
Affinity DataIC50: 3.90nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753481BDBM753481(6-(2-methoxyethoxy)-4-(6-(6-((6-methoxypyridin-3-y...)
Affinity DataIC50: 4.10nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753587BDBM753587(6-(2,2-difluoroethoxy)-4-(5-(6-((6-methoxypyridin-...)
Affinity DataIC50: 4.30nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753582BDBM753582(1-(4-(5-(6-(2-fluoroethoxy)-1H-pyrazolo[3',4':3,4]...)
Affinity DataIC50: 4.80nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753524BDBM753524(6-(2-(difluoromethoxy)ethoxy)-4-(6-(6-((6-methoxyp...)
Affinity DataIC50: 4.80nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 677953BDBM677953(US20240174674, Compound 297 | US12338253, Compound...)
Affinity DataIC50: 5.90nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753580BDBM753580(6-(2-bromoethoxy)-4-(6-(6-((6-methoxypyridin-3-yl)...)
Affinity DataIC50: 7.90nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753577BDBM753577(6-butoxy-((4-(6-(6-((6-methoxypyridin-3-yl)methyl)...)
Affinity DataIC50: 10.1nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753574BDBM753574(6-(benzyloxy)-4-(6-(6-((6-methoxypyridin-3-yl)meth...)
Affinity DataIC50: 16.2nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753581BDBM753581(N,N-diethyl-4-(5-(6-(2-fluoroethoxy)-1H-pyrazolo[3...)
Affinity DataIC50: 18.9nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 50021574BDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 20.2nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753569BDBM753569(6-isobutoxy-4-(6-(6-((6-methoxypyridin-3-yl)methyl...)
Affinity DataIC50: 30.5nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandChemical structure of BindingDB Monomer ID 753575BDBM753575(4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazab...)
Affinity DataIC50: 38.4nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

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