Compile Data Set for Download or QSAR
Report error Found 1510 Enz. Inhib. hit(s) with all data for entry = 11888
TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 12.9nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657583(US20240083857, Example 262 | N-[1-(5-{2-[(dimethyl...)
Affinity DataIC50: 15.5nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657746(N-[1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-...)
Affinity DataIC50: 23nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 27.7nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657730(N-[1-{5-[2-(aminomethyl)-6-chlorophenyl]thiophen-2...)
Affinity DataIC50: 28nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657737(N-[1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-...)
Affinity DataIC50: 28.9nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 29.1nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657613(N-[1-{5-[2-(aminomethyl)-5-chlorophenyl]thiophen-2...)
Affinity DataIC50: 31.5nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657746(N-[1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-...)
Affinity DataIC50: 31.5nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657730(N-[1-{5-[2-(aminomethyl)-6-chlorophenyl]thiophen-2...)
Affinity DataIC50: 31.6nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657746(N-[1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-...)
Affinity DataIC50: 33.2nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657737(N-[1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-...)
Affinity DataIC50: 35.3nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657583(US20240083857, Example 262 | N-[1-(5-{2-[(dimethyl...)
Affinity DataIC50: 36.7nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657583(US20240083857, Example 262 | N-[1-(5-{2-[(dimethyl...)
Affinity DataIC50: 37.9nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657531(1-[2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-yl...)
Affinity DataIC50: 38.5nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657613(N-[1-{5-[2-(aminomethyl)-5-chlorophenyl]thiophen-2...)
Affinity DataIC50: 38.7nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657762(N-[1-(5-{2-[(dimethylamino)methyl]-4-methylphenyl}...)
Affinity DataIC50: 39.4nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657644(N-[1-(5-{4-chloro-2-[(dimethylamino)methyl]phenyl}...)
Affinity DataIC50: 39.5nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657738(N-[1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-...)
Affinity DataIC50: 39.8nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657777(1-benzyl-4-(4-{[1-(5-{2-[(dimethylamino)methyl]phe...)
Affinity DataIC50: 40nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657583(US20240083857, Example 262 | N-[1-(5-{2-[(dimethyl...)
Affinity DataIC50: 40.3nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657613(N-[1-{5-[2-(aminomethyl)-5-chlorophenyl]thiophen-2...)
Affinity DataIC50: 41.3nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657505(6,7-dimethoxy-2-methyl-N-[1-{5-[2-(pyrrolidin-1-yl...)
Affinity DataIC50: 41.6nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657583(US20240083857, Example 262 | N-[1-(5-{2-[(dimethyl...)
Affinity DataIC50: 44nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657762(N-[1-(5-{2-[(dimethylamino)methyl]-4-methylphenyl}...)
Affinity DataIC50: 45.1nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657738(N-[1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-...)
Affinity DataIC50: 45.1nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657762(N-[1-(5-{2-[(dimethylamino)methyl]-4-methylphenyl}...)
Affinity DataIC50: 45.3nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657737(N-[1-(5-{2-[(dimethylamino)methyl]phenyl}thiophen-...)
Affinity DataIC50: 45.5nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657777(1-benzyl-4-(4-{[1-(5-{2-[(dimethylamino)methyl]phe...)
Affinity DataIC50: 45.5nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657618(2-{[2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-y...)
Affinity DataIC50: 46nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657619(2-{[2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-y...)
Affinity DataIC50: 47.2nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657777(1-benzyl-4-(4-{[1-(5-{2-[(dimethylamino)methyl]phe...)
Affinity DataIC50: 48nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657678(N-[1-{5-[2-(2-aminoethyl)phenyl]thiophen-2-yl}ethy...)
Affinity DataIC50: 48.8nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657730(N-[1-{5-[2-(aminomethyl)-6-chlorophenyl]thiophen-2...)
Affinity DataIC50: 49.2nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657619(2-{[2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-y...)
Affinity DataIC50: 49.3nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657747(N-{2-[(4-{[1-(5-{2-[(dimethylamino)methyl]phenyl}t...)
Affinity DataIC50: 49.8nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657571(6,7-dimethoxy-2-methyl-N-[1-(5-{2-[(methylamino)me...)
Affinity DataIC50: 50nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657503(6,7-di methoxy-2-methyl-N-[1-{5-[2-(2-oxa-6-azaspi...)
Affinity DataIC50: 51nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657583(US20240083857, Example 262 | N-[1-(5-{2-[(dimethyl...)
Affinity DataIC50: 51.1nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657678(N-[1-{5-[2-(2-aminoethyl)phenyl]thiophen-2-yl}ethy...)
Affinity DataIC50: 51.2nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657755(4-(4-{[1-(5-{2-[(dimethylamino)methyl]phenyl}thiop...)
Affinity DataIC50: 51.9nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657626(6,7-dimethoxy-2-methyl-N-[1-{5-[2-(piperazin-1-ylm...)
Affinity DataIC50: 55.2nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657618(2-{[2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-y...)
Affinity DataIC50: 57.8nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657571(6,7-dimethoxy-2-methyl-N-[1-(5-{2-[(methylamino)me...)
Affinity DataIC50: 58.1nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657626(6,7-dimethoxy-2-methyl-N-[1-{5-[2-(piperazin-1-ylm...)
Affinity DataIC50: 58.4nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657747(N-{2-[(4-{[1-(5-{2-[(dimethylamino)methyl]phenyl}t...)
Affinity DataIC50: 58.4nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657619(2-{[2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-y...)
Affinity DataIC50: 58.8nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 60.5nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657763(N-[1-(5-{4-cyclopropyl-2-[(dimethylamino)methyl]ph...)
Affinity DataIC50: 60.5nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657618(2-{[2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-y...)
Affinity DataIC50: 60.6nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent

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