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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668316(7-(3-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a]py...)
Affinity DataKi:  0.490nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668310(US20240124456, Compound (-)-I-2)
Affinity DataKi:  1.75nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  5.95nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
In DepthDetails US Patent
DrugBank


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668309(US20240124456, Compound (+)-I-2)
Affinity DataKi:  8.87nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668308(7-(4(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a]pyr...)
Affinity DataKi:  9.03nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668335(1-(4-fluorobenzene)-4-(4,6,6a,7,9,10-hexahydro-8H-...)
Affinity DataKi:  10.8nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668323(N-(4-(2-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a...)
Affinity DataKi:  16.3nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668321(N-(4-(2-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a...)
Affinity DataKi:  22.2nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668319(US20240124456, Compound (-)-I-10)
Affinity DataKi:  22.4nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668322(N-(4-(2-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a...)
Affinity DataKi:  27.1nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668312(5-(4-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a]py...)
Affinity DataKi:  30.3nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668334(1-(4-fluorobenzene)-4-(4,6,6a,7,9,10-hexahydro-8H-...)
Affinity DataKi:  32.4nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668331((E)-74(4-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-...)
Affinity DataKi:  33.2nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668307(7-(4(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a]pyr...)
Affinity DataKi:  33.6nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668313(6-(4-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a]py...)
Affinity DataKi:  37.1nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668324(N-(4-(2-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a...)
Affinity DataKi:  40.7nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668311(5-(4-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a]py...)
Affinity DataKi:  49.6nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668318(3-(4-(2-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a...)
Affinity DataKi:  50.6nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668314(US20240124456, Compound I-6)
Affinity DataKi:  51.6nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668329(1,1-dimethyl-3-(4-(2-(4-methyl-4,6,6a,7,9,10-hexah...)
Affinity DataKi:  52.7nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668327(3-(2-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a]py...)
Affinity DataKi:  55.8nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668328(7-(4-(4-methyl-4,6,6a,7,9,10-hexahydro-8H-pyrazino...)
Affinity DataKi:  61nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668330((E)-7-(4-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-...)
Affinity DataKi:  70.9nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668325(N-(4-(2-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a...)
Affinity DataKi:  77.5nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668333((E)-7-((4-(4-methyl-4,6,6a,7,9,10-hexahydro-8H-pyr...)
Affinity DataKi:  100nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668332((E)-7-((4-(4-methyl-4,6,6a,7,9,10-hexahydro-8H-pyr...)
Affinity DataKi:  176nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668337(1-(4-fluorobenzene)-4-(4-methyl-4,6,6a,7,9,10-hexa...)
Affinity DataKi:  383nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668315(7-(3-(4,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a]py...)
Affinity DataKi:  403nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668317(8-(3-(benzo[d][1,3]dioxo1-5-yloxy)propyl)-6,6a,7,8...)
Affinity DataKi:  752nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668320(US20240124456, Compound (+)-I-10)
Affinity DataKi:  1.14E+3nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668336(1-(4-fluorobenzene)-4-(4-methyl-4,6,6a,7,9,10-hexa...)
Affinity DataKi:  1.35E+3nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668326(3-(4-04,6,6a,7,9,10-hexahydro-8H-pyrazino[1,2-a]py...)
Affinity DataKi:  1.99E+3nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent