Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 12003
TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669536BDBM669536(US20240132473, Compound I-9)
Affinity DataIC50: 0.200nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669533BDBM669533(US20240132473, Compound I-6)
Affinity DataIC50: 0.200nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669528BDBM669528(US20240132473, Compound I-1)
Affinity DataIC50: 0.300nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669539BDBM669539(US20240132473, Compound I-12)
Affinity DataIC50: 0.300nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669553BDBM669553(US20240132473, Compound I-26)
Affinity DataIC50: 0.300nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669531BDBM669531(US20240132473, Compound I-4)
Affinity DataIC50: 0.300nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669549BDBM669549(US20240132473, Compound I-22)
Affinity DataIC50: 0.300nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669560BDBM669560(US20240132473, Compound I-33)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669545BDBM669545(US20240132473, Compound I-18)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669540BDBM669540(US20240132473, Compound I-13)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669532BDBM669532(US20240132473, Compound I-5)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669550BDBM669550(US20240132473, Compound I-23)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669544BDBM669544(US20240132473, Compound I-17)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669559BDBM669559(US20240132473, Compound I-32)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669543BDBM669543(US20240132473, Compound I-16)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669561BDBM669561(US20240132473, Compound I-34)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669529BDBM669529(US20240132473, Compound I-2)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669552BDBM669552(US20240132473, Compound I-25)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669538BDBM669538(US20240132473, Compound I-11)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669548BDBM669548(US20240132473, Compound I-21)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669563BDBM669563(US20240132473, Compound I-36)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669534BDBM669534(US20240132473, Compound I-7)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669530BDBM669530(US20240132473, Compound I-3)
Affinity DataIC50: 0.600nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669556BDBM669556(US20240132473, Compound I-29)
Affinity DataIC50: 0.600nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669558BDBM669558(US20240132473, Compound I-31)
Affinity DataIC50: 0.600nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669557BDBM669557(US20240132473, Compound I-30)
Affinity DataIC50: 0.600nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669541BDBM669541(US20240132473, Compound I-14)
Affinity DataIC50: 0.600nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669535BDBM669535(US20240132473, Compound I-8)
Affinity DataIC50: 0.600nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669547BDBM669547(US20240132473, Compound I-20)
Affinity DataIC50: 0.600nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669562BDBM669562(US20240132473, Compound I-35)
Affinity DataIC50: 0.700nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669555BDBM669555(US20240132473, Compound I-28)
Affinity DataIC50: 0.700nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669542BDBM669542(US20240132473, Compound I-15)
Affinity DataIC50: 0.700nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669554BDBM669554(US20240132473, Compound I-27)
Affinity DataIC50: 0.700nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669546BDBM669546(US20240132473, Compound I-19)
Affinity DataIC50: 0.800nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669551BDBM669551(US20240132473, Compound I-24)
Affinity DataIC50: 0.800nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669537BDBM669537(US20240132473, Compound I-10)
Affinity DataIC50: 1.10nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 395296BDBM395296(N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-...)
Affinity DataIC50: 8.70nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669524BDBM669524(US20240132473, Compound BAY-1834845)
Affinity DataIC50: 15.2nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669527BDBM669527(US20240132473, Compound MY-004-103)
Affinity DataIC50: 137nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Xunhe Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 669526BDBM669526(US20240132473, Compound MY-004-102)
Affinity DataIC50: 152nMAssay Description:The inhibitory activity (IC50) of the compound on IRAK4 kinase under Km ATP was detected by mobility shift assay (MSA). Ten drug concentration gradie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent