Compile Data Set for Download or QSAR
Report error Found 100 Enz. Inhib. hit(s) with all data for entry = 12044
TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674464(NMePip-Phe-hPhe-VSPh | US20240150396, Compound K11...)
Affinity DataKi:  0.200nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM50286450([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataKi:  0.310nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50286450([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataKi:  0.440nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCathepsin S(Human)
Texas A&M University

US Patent
LigandPNGBDBM674464(NMePip-Phe-hPhe-VSPh | US20240150396, Compound K11...)
Affinity DataKi:  0.600nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674464(NMePip-Phe-hPhe-VSPh | US20240150396, Compound K11...)
Affinity DataKi:  2nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674464(NMePip-Phe-hPhe-VSPh | US20240150396, Compound K11...)
Affinity DataKi:  2nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674464(NMePip-Phe-hPhe-VSPh | US20240150396, Compound K11...)
Affinity DataKi:  2nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674495(US20240150396, Compound 42 BC666)
Affinity DataKi:  2.10nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674495(US20240150396, Compound 42 BC666)
Affinity DataKi:  2.30nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674465(Cbz-Phe-Phe-VSPh | US20240150396, Compound 1)
Affinity DataKi:  3.60nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCathepsin B(Human)
Texas A&M University

US Patent
LigandPNGBDBM674464(NMePip-Phe-hPhe-VSPh | US20240150396, Compound K11...)
Affinity DataKi:  5.70nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

US Patent
LigandPNGBDBM674496(US20240150396, Compound 43 LL-478)
Affinity DataKi:  9nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674493(US20240150396, Compound 35 LL322)
Affinity DataKi:  10.8nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674493(US20240150396, Compound 35 LL322)
Affinity DataKi:  18nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674494(US20240150396, Compound 36 BC552A)
Affinity DataKi:  20nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674487(US20240150396, Compound 29 LL127)
Affinity DataKi:  22nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674490(US20240150396, Compound 34 LL294 | US20240150396, ...)
Affinity DataKi:  23nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674490(US20240150396, Compound 34 LL294 | US20240150396, ...)
Affinity DataKi:  27nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674488(US20240150396, Compound 30 LL166)
Affinity DataKi:  28nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674489(US20240150396, Compound 31 LL232)
Affinity DataKi:  38nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674498(US20240150396, Compound 45 BC-671)
Affinity DataKi:  39nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674494(US20240150396, Compound 36 BC552A)
Affinity DataKi:  47nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674490(US20240150396, Compound 34 LL294 | US20240150396, ...)
Affinity DataKi:  48nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674488(US20240150396, Compound 30 LL166)
Affinity DataKi:  49nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674496(US20240150396, Compound 43 LL-478)
Affinity DataKi:  50nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674490(US20240150396, Compound 34 LL294 | US20240150396, ...)
Affinity DataKi:  58nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

US Patent
LigandPNGBDBM674497(US20240150396, Compound 44 LL-482)
Affinity DataKi:  60nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

US Patent
LigandPNGBDBM674499(US20240150396, Compound 46 BC-674)
Affinity DataKi:  60nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674490(US20240150396, Compound 34 LL294 | US20240150396, ...)
Affinity DataKi:  74nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674490(US20240150396, Compound 34 LL294 | US20240150396, ...)
Affinity DataKi:  103nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50514676(CHEMBL4519086 | US20240150396, Compound 15)
Affinity DataKi:  126nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50514676(CHEMBL4519086 | US20240150396, Compound 15)
Affinity DataKi:  126nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50514676(CHEMBL4519086 | US20240150396, Compound 15)
Affinity DataKi:  126nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetProcathepsin L(Human)
Texas A&M University

US Patent
LigandPNGBDBM674497(US20240150396, Compound 44 LL-482)
Affinity DataKi:  140nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

US Patent
LigandPNGBDBM674502(US20240150396, Compound 49 BC-742B)
Affinity DataKi:  143nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50514684(CHEMBL4434867 | US20240150396, Compound 13)
Affinity DataKi:  171nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50514684(CHEMBL4434867 | US20240150396, Compound 13)
Affinity DataKi:  171nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50514684(CHEMBL4434867 | US20240150396, Compound 13)
Affinity DataKi:  171nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

US Patent
LigandPNGBDBM674498(US20240150396, Compound 45 BC-671)
Affinity DataKi:  190nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

US Patent
LigandPNGBDBM674500(US20240150396, Compound 47 LL-482)
Affinity DataKi:  260nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674472(Cbz-Phe-Phe-vinyl-2PyrNMe | US20240150396, Compoun...)
Affinity DataKi:  280nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674472(Cbz-Phe-Phe-vinyl-2PyrNMe | US20240150396, Compoun...)
Affinity DataKi:  280nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674472(Cbz-Phe-Phe-vinyl-2PyrNMe | US20240150396, Compoun...)
Affinity DataKi:  280nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50514673(CHEMBL4544942 | US20240150396, Compound 11)
Affinity DataKi:  310nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50514673(CHEMBL4544942 | US20240150396, Compound 11)
Affinity DataKi:  310nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50514673(CHEMBL4544942 | US20240150396, Compound 11)
Affinity DataKi:  310nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCathepsin S(Human)
Texas A&M University

US Patent
LigandPNGBDBM50514676(CHEMBL4519086 | US20240150396, Compound 15)
Affinity DataKi:  320nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM674489(US20240150396, Compound 31 LL232)
Affinity DataKi:  350nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50514672(CHEMBL4556756 | US20240150396, Compound 7)
Affinity DataKi:  364nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
Texas A&M University

US Patent
LigandPNGBDBM50514672(CHEMBL4556756 | US20240150396, Compound 7)
Affinity DataKi:  364nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

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