Compile Data Set for Download or QSAR
Report error Found 85 Enz. Inhib. hit(s) with all data for entry = 12228
LigandPNGBDBM688771(US20240190889, Example 16 | (7S,13R)-13-(difluorom...)
Affinity DataKi:  1nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688760(US20240190889, Example 5 | (7S,13R)-13-(difluorome...)
Affinity DataKi:  1.20nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688759(US20240190889, Example 4 | (13R)-9-(2-chloro-6-flu...)
Affinity DataKi:  1.20nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688770(US20240190889, Example 15 | (7S,13R)-9-(2,6-difluo...)
Affinity DataKi:  1.40nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  1.5nMAssay Description:The affinity of compounds at GABAA γ2 subunit-containing receptors was measured by competition for [3H]Flumazenil (81.1 Ci/mmol; Roche) binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688769(US20240190889, Example 14 | (13R)-9-(2,6-difluorop...)
Affinity DataKi:  1.60nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688764(US20240190889, Example 9 | (7S,13R)-9-(2-chloro-6-...)
Affinity DataKi:  1.60nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688758(US20240190889, Example 3 | (13R)-13-(difluoromethy...)
Affinity DataKi:  1.80nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688763(US20240190889, Example 8 | (7S,13R)-3-cyclopropyl-...)
Affinity DataKi:  1.90nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688762(US20240190889, Example 7 | (13R)-3-cyclopropyl-13-...)
Affinity DataKi:  2.10nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688775(US20240190889, Example 20 | (7S,13R)-13-(difluorom...)
Affinity DataKi:  2.24nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688771(US20240190889, Example 16 | (7S,13R)-13-(difluorom...)
Affinity DataKi:  2.30nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688773(US20240190889, Example 18 | (7S,13R)-13-(difluorom...)
Affinity DataKi:  2.5nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688783(US20240190889, Example RE-C)
Affinity DataKi:  2.59nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688769(US20240190889, Example 14 | (13R)-9-(2,6-difluorop...)
Affinity DataKi:  2.80nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688758(US20240190889, Example 3 | (13R)-13-(difluoromethy...)
Affinity DataKi:  2.90nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688776(US20240190889, Example 21 | [(7S,13R)-13-(difluoro...)
Affinity DataKi:  2.97nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688765(US20240190889, Example 10 | (13R)-13-(difluorometh...)
Affinity DataKi:  3nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688765(US20240190889, Example 10 | (13R)-13-(difluorometh...)
Affinity DataKi:  3nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688760(US20240190889, Example 5 | (7S,13R)-13-(difluorome...)
Affinity DataKi:  3.40nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688761(US20240190889, Example 6 | (13R)-9-(2-chloro-6-flu...)
Affinity DataKi:  3.40nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688766(US20240190889, Example 11 | (7S,13R)-9-(2-chloro-6...)
Affinity DataKi:  3.40nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688764(US20240190889, Example 9 | (7S,13R)-9-(2-chloro-6-...)
Affinity DataKi:  3.60nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688775(US20240190889, Example 20 | (7S,13R)-13-(difluorom...)
Affinity DataKi:  3.60nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688767(US20240190889, Example 12 | (7S,13R)-9-(2-chloro-6...)
Affinity DataKi:  3.70nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688763(US20240190889, Example 8 | (7S,13R)-3-cyclopropyl-...)
Affinity DataKi:  4.60nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688774(US20240190889, Example 19 | [(7S,13R)-13-(difluoro...)
Affinity DataKi:  4.60nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688759(US20240190889, Example 4 | (13R)-9-(2-chloro-6-flu...)
Affinity DataKi:  4.60nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688776(US20240190889, Example 21 | [(7S,13R)-13-(difluoro...)
Affinity DataKi:  4.70nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM21363(12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triaza...)
Affinity DataKi:  5nMAssay Description:The affinity of compounds at GABAA γ2 subunit-containing receptors was measured by competition for [3H]Flumazenil (81.1 Ci/mmol; Roche) binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688774(US20240190889, Example 19 | [(7S,13R)-13-(difluoro...)
Affinity DataKi:  5.40nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688773(US20240190889, Example 18 | (7S,13R)-13-(difluorom...)
Affinity DataKi:  5.70nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688768(US20240190889, Example 13 | (7S,13R)-9-(2,6-difluo...)
Affinity DataKi:  5.90nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688770(US20240190889, Example 15 | (7S,13R)-9-(2,6-difluo...)
Affinity DataKi:  6.30nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688762(US20240190889, Example 7 | (13R)-3-cyclopropyl-13-...)
Affinity DataKi:  6.40nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688781(US20240190889, Example RE-A)
Affinity DataKi:  6.60nMAssay Description:The affinity of compounds at GABAA γ2 subunit-containing receptors was measured by competition for [3H]Flumazenil (81.1 Ci/mmol; Roche) binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688761(US20240190889, Example 6 | (13R)-9-(2-chloro-6-flu...)
Affinity DataKi:  6.60nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688731(US20240190889, Example 1 | (13R)-9-(2-chloro-6-flu...)
Affinity DataKi:  8.80nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688777(US20240190889, Example 22 | [(7S,13S)-13-(difluoro...)
Affinity DataKi:  10.2nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688766(US20240190889, Example 11 | (7S,13R)-9-(2-chloro-6...)
Affinity DataKi:  10.3nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688767(US20240190889, Example 12 | (7S,13R)-9-(2-chloro-6...)
Affinity DataKi:  13.4nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688760(US20240190889, Example 5 | (7S,13R)-13-(difluorome...)
Affinity DataKi:  14.4nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688768(US20240190889, Example 13 | (7S,13R)-9-(2,6-difluo...)
Affinity DataKi:  16.2nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688757(US20240190889, Example 2 | (13R)-9-(2,6-difluoroph...)
Affinity DataKi:  16.3nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688758(US20240190889, Example 3 | (13R)-13-(difluoromethy...)
Affinity DataKi:  16.8nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688783(US20240190889, Example RE-C)
Affinity DataKi:  17.2nMAssay Description:The affinity of compounds at GABAA γ2 subunit-containing receptors was measured by competition for [3H]Flumazenil (81.1 Ci/mmol; Roche) binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688781(US20240190889, Example RE-A)
Affinity DataKi:  17.5nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM50001728(CHEMBL661 | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]t...)
Affinity DataKi:  19.6nMAssay Description:The affinity of compounds at GABAA γ2 subunit-containing receptors was measured by competition for [3H]Flumazenil (81.1 Ci/mmol; Roche) binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688783(US20240190889, Example RE-C)
Affinity DataKi:  20.4nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

LigandPNGBDBM688731(US20240190889, Example 1 | (13R)-9-(2-chloro-6-flu...)
Affinity DataKi:  25.4nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

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