Compile Data Set for Download or QSAR
Report error Found 152 Enz. Inhib. hit(s) with all data for entry = 12586
TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712395(XZ2701 | US20250011330, Compound (E)-106-D1)
Affinity DataIC50: 380nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712384((E)-4-((2-(4-((((4-(5-Cyanopyridin-2-yl)benzyliden...)
Affinity DataIC50: 380nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712341(US20250011330, Compound 8m)
Affinity DataIC50: 900nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712352(US20250011330, Compound 7b)
Affinity DataIC50: 1.50E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712342(US20250011330, Compound 8n)
Affinity DataIC50: 1.50E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712343(US20250011330, Compound 8o)
Affinity DataIC50: 1.60E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712345(US20250011330, Compound 8q)
Affinity DataIC50: 1.80E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712344(US20250011330, Compound 8p)
Affinity DataIC50: 1.80E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712339(US20250011330, Compound 8k)
Affinity DataIC50: 2.40E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712402(4-((2-(4-(2-((4-(5-((λ2-Azaneylidene)-λ3-methyl)py...)
Affinity DataIC50: 2.75E+3nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712394(4-((2,7-Diphenylimidazo[1,2-a]pyridin-3-yl)amino)b...)
Affinity DataIC50: 2.98E+3nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712349(US20250011330, Compound M7)
Affinity DataIC50: 3.00E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712386((E)-4-((7-Phenyl-2-(4-((((4-(pyrazin-2-yl)benzylid...)
Affinity DataIC50: 3.10E+3nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712400(4-((2-(4-(1-(4-(5-Cyanopyridin-2-yl)benzyl)-1H-1,2...)
Affinity DataIC50: 3.10E+3nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712333(US20250011330, Compound 8e)
Affinity DataIC50: 3.20E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712382(4-((2,7-Diphenylimidazo[1,2-a]pyridin-3-yl)amino)b...)
Affinity DataIC50: 3.53E+3nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712347(US20250011330, Compound 8s)
Affinity DataIC50: 4.00E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712332(US20250011330, Compound 8d)
Affinity DataIC50: 4.20E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712383((Z)-4-((2-(4-((((4-(5-Cyanopyridin-2-yl)benzyliden...)
Affinity DataIC50: 5.65E+3nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712424(4-((2-(4-((4-(((2-(2,6-Dioxopiperidin-3-yl)-1,3-di...)
Affinity DataIC50: 7.41E+3nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712387((Z)-4-((2-(4-((((4-(2-Oxopyrrolidin-1-yl)benzylide...)
Affinity DataIC50: 7.67E+3nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712377(US20250011330, Compound XZ615)
Affinity DataIC50: 7.87E+3nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712393(XZ615 | US20250011330, Compound 102)
Affinity DataIC50: 7.87E+3nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712386((E)-4-((7-Phenyl-2-(4-((((4-(pyrazin-2-yl)benzylid...)
Affinity DataIC50: 8.80E+3nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712329(US20250011330, Compound 8a)
Affinity DataIC50: 9.30E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712346(US20250011330, Compound 8r)
Affinity DataIC50: 9.95E+3nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712388((E)-4-((2-(4-((((4-(2-Oxopyrrolidin-1-yl)benzylide...)
Affinity DataIC50: 1.02E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712388((E)-4-((2-(4-((((4-(2-Oxopyrrolidin-1-yl)benzylide...)
Affinity DataIC50: 1.09E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712348(US20250011330, Compound 10b)
Affinity DataIC50: 1.10E+4nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712424(4-((2-(4-((4-(((2-(2,6-Dioxopiperidin-3-yl)-1,3-di...)
Affinity DataIC50: 1.12E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712426(4-((2-(4-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-...)
Affinity DataIC50: 1.23E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712331(US20250011330, Compound 8c)
Affinity DataIC50: 1.27E+4nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712330(US20250011330, Compound 8b)
Affinity DataIC50: 1.48E+4nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712328(US20250011330, Compound 6u)
Affinity DataIC50: 1.61E+4nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712426(4-((2-(4-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-...)
Affinity DataIC50: 1.68E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712379((E)-4-((6-((((4-(5-cyanopyridin-2-yl)benzylidene)a...)
Affinity DataIC50: 1.74E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712404(US20250011330, Compound XZ730)
Affinity DataIC50: 1.78E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712404(US20250011330, Compound XZ730)
Affinity DataIC50: 1.78E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712356(US20250011330, Compound 7f)
Affinity DataIC50: 1.80E+4nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712425(4-((2-(4-((4-(((2-(2,6-Dioxopiperidin-3-yl)-1,3-di...)
Affinity DataIC50: 1.85E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712355(US20250011330, Compound 7e)
Affinity DataIC50: 2.00E+4nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712425(4-((2-(4-((4-(((2-(2,6-Dioxopiperidin-3-yl)-1,3-di...)
Affinity DataIC50: 2.12E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712399(4-((2-(4-(1-(4-(5-Cyanopyridin-2-yl)benzyl)-1H-1,2...)
Affinity DataIC50: 2.16E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712340(US20250011330, Compound 8l)
Affinity DataIC50: 2.20E+4nMAssay Description:Table 1 and 2: TDP1 Gel-based in vitro assay was carried out as previously described Lountos, G. T., et al. (Nucleic Acids Res. (2019) 47(19) 10134-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712408(4-((Fluorosulfonyl)(2-(2-((fluorosulfonyl)oxy)phen...)
Affinity DataIC50: 2.27E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712398(4-((2-(4-((1-(4-(5-Cyanopyridin-2-yl)benzyl)-1H-1,...)
Affinity DataIC50: 2.35E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712401(4-((2-(4-(2-((4-(5-((λ2-Azaneylidene)-λ3-methyl)py...)
Affinity DataIC50: 2.51E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712403(US20250011330, Compound XZ725)
Affinity DataIC50: 2.56E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712400(4-((2-(4-(1-(4-(5-Cyanopyridin-2-yl)benzyl)-1H-1,2...)
Affinity DataIC50: 2.59E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Department Of Health and Human Services

US Patent
LigandPNGBDBM712395(XZ2701 | US20250011330, Compound (E)-106-D1)
Affinity DataIC50: 2.81E+4nMAssay Description:The oximes were evaluated by gel-based TDP1 fluorescence assay in a concentration of 100 μM in DMSO. The fluorescence of DMSO blank vial was set as 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

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