Compile Data Set for Download or QSAR
Report error Found 124 Enz. Inhib. hit(s) with all data for entry = 12667
TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718936(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((2R,7...)
Affinity DataIC50: 0.0680nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718956(US20250042919, Compound 41A)
Affinity DataIC50: 0.115nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718942(6-((2R,5S,5aS,6S,9R)-3-chloro- 13-(((3R)-2',2'-dif...)
Affinity DataIC50: 0.117nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718941(6-((2R,5S,5aS,6S,9R)-3-chloro- 13-(((3S)-2',2'-dif...)
Affinity DataIC50: 0.118nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718950(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((S,Z)...)
Affinity DataIC50: 0.130nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718951(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((3R)-...)
Affinity DataIC50: 0.134nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718955(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((S,Z)...)
Affinity DataIC50: 0.140nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718949(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((6S,8...)
Affinity DataIC50: 0.150nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718954(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((2R,7...)
Affinity DataIC50: 0.190nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718969(6-((2R,5aS,6R,9R)-3-Chloro-1-fluoro-13-(((S,Z)-2- ...)
Affinity DataIC50: 0.190nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718938(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((2S,4...)
Affinity DataIC50: 0.200nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718943(US20250042919, Compound 30A)
Affinity DataIC50: 0.228nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718932(US20250042919, Compound 20B)
Affinity DataIC50: 0.25nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718908(6-((2R,5aS,6S,9R)-3-chloro-1- fluoro-13-(((S)-2- m...)
Affinity DataIC50: 0.298nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718968(6-((2R,5aS,6R,9R)-3-Chloro-1-fluoro-13-(((S,Z)-2- ...)
Affinity DataIC50: 0.325nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718961(US20250042919, Compound 43B)
Affinity DataIC50: 0.330nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718913(6-((2R,5aS,6S,9R)-3-chloro-13- (((S)-2- (difluorom...)
Affinity DataIC50: 0.361nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718965(6-((2R,5aS,6R,9R)-3-Chloro-1-fluoro-13-(((2R,7aS)-...)
Affinity DataIC50: 0.370nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718930(6-((5aS,6S,9R)-1-fluoro-13-(((S)- 2-methylenetetra...)
Affinity DataIC50: 0.384nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718910(6-((2R,5aS,6S,9R)-3-chloro-1- fluoro-13-(((S,Z)-2-...)
Affinity DataIC50: 0.389nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718917(6-((2R,5aS,6S,9R)-3-chloro-1- fluoro-13-((3-methyl...)
Affinity DataIC50: 0.397nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718964(US20250042919, Compound 45B)
Affinity DataIC50: 0.495nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718928((5aS,6S,9R)-3-chloro-1-fluoro-2- (6-fluoro-1-methy...)
Affinity DataIC50: 0.5nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718915(US20250042919, Compound 6B)
Affinity DataIC50: 0.514nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718944(US20250042919, Compound 30B)
Affinity DataIC50: 0.560nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718966(6-((2R,5aS,6R,9R)-3-Chloro-1-fluoro-13-(((2R,7aS)-...)
Affinity DataIC50: 0.600nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718967(4-((2R,5aS,6R,9R)-2-(6-Amino-4-methyl-3- (trifluor...)
Affinity DataIC50: 0.640nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718922(6-((10R,13aR)-11-chloro-9- fluoro-7-(((S)-2- methy...)
Affinity DataIC50: 0.700nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718927((5aS,6S,9R)-3-chloro-2-(6-fluoro- 1-methyl-1H-inda...)
Affinity DataIC50: 0.710nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718952(6-((2R,5S,5aS,6S,9R)-3-chloro- 13-((3,3-difluoro-1...)
Affinity DataIC50: 0.740nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718922(6-((10R,13aR)-11-chloro-9- fluoro-7-(((S)-2- methy...)
Affinity DataIC50: 0.800nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718933(6-((2R,5aS,6S,9R)-3-chloro-1- fluoro-13-(((2R,7aS)...)
Affinity DataIC50: 1.06nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718925(6-((5aS,6S,9R)-3-chloro-13- (((S)-2-methylenetetra...)
Affinity DataIC50: 1.12nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718942(6-((2R,5S,5aS,6S,9R)-3-chloro- 13-(((3R)-2',2'-dif...)
Affinity DataIC50: 1.42nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718950(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((S,Z)...)
Affinity DataIC50: 1.44nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718941(6-((2R,5S,5aS,6S,9R)-3-chloro- 13-(((3S)-2',2'-dif...)
Affinity DataIC50: 1.5nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718908(6-((2R,5aS,6S,9R)-3-chloro-1- fluoro-13-(((S)-2- m...)
Affinity DataIC50: 1.72nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718920(6-((2R,5aS,6S,9R)-3-chloro-13- (((R)-2,2-difluorot...)
Affinity DataIC50: 1.77nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718962(2-((5S,5aS,6S,9R)-3-Chloro-1- fluoro-13-(((2R,7aS)...)
Affinity DataIC50: 1.81nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718921(6-((2R,5aS,6S,9R)-3-chloro-13- (((S)-2,2-difluorot...)
Affinity DataIC50: 2.15nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718910(6-((2R,5aS,6S,9R)-3-chloro-1- fluoro-13-(((S,Z)-2-...)
Affinity DataIC50: 2.55nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718924(6-((5aS,6S,9R)-3-chloro-13- (((S)-2-methylenetetra...)
Affinity DataIC50: 2.56nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718939(6-((2R,5S,5aS,6S,9R)-13-((2- oxabicyclo[2.1.1]hexa...)
Affinity DataIC50: 2.57nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718914(US20250042919, Compound 6A)
Affinity DataIC50: 2.59nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718911(6-((2R,5aS,6S,9R)-3-chloro-1- fluoro-15-methyl-13-...)
Affinity DataIC50: 2.92nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718936(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((2R,7...)
Affinity DataIC50: 2.97nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718917(6-((2R,5aS,6S,9R)-3-chloro-1- fluoro-13-((3-methyl...)
Affinity DataIC50: 3.16nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718935(US20250042919, Compound 22B)
Affinity DataIC50: 3.17nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718912(1-((2R,5aS,6S,9R)-2-(6-amino-4- methyl-3-(trifluor...)
Affinity DataIC50: 3.34nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718913(6-((2R,5aS,6S,9R)-3-chloro-13- (((S)-2- (difluorom...)
Affinity DataIC50: 4nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

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