Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 12781
Affinity DataIC50: 0.0500nMAssay Description:Assays contained 25 pM cathepsin L (RD systems: 952-CY-010), 5 uM LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 20 mM KPO4, p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Assays contained 25 pM cathepsin L (RD systems: 952-CY-010), 5 uM LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 20 mM KPO4, p...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology
US Patent
The Wistar Institute of Anatomy and Biology
US Patent
Affinity DataIC50: 11nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology
US Patent
The Wistar Institute of Anatomy and Biology
US Patent
Affinity DataIC50: 18nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Assays contained 0.6 nM cathepsin B (RD systems: 953-CY-010), 25 uM Z-LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 50 mM MES...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Assays contained 0.6 nM cathepsin B (RD systems: 953-CY-010), 25 uM Z-LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 50 mM MES...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology
US Patent
The Wistar Institute of Anatomy and Biology
US Patent
Affinity DataIC50: 230nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology
US Patent
The Wistar Institute of Anatomy and Biology
US Patent
Affinity DataIC50: 580nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology
US Patent
The Wistar Institute of Anatomy and Biology
US Patent
Affinity DataIC50: 620nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Assays contained 0.6 nM cathepsin B (RD systems: 953-CY-010), 25 uM Z-LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 50 mM MES...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Assays contained 25 pM thrombin (RD systems: 1473-SE-010), 25 uM BOC—PVR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 μL of 50 mM Tri...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Assays contained 25 pM thrombin (RD systems: 1473-SE-010), 25 uM BOC—PVR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 μL of 50 mM Tri...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Assays contained 0.6 nM cathepsin B (RD systems: 953-CY-010), 25 uM Z-LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 50 mM MES...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Assays contained 0.6 nM cathepsin B (RD systems: 953-CY-010), 25 uM Z-LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 50 mM MES...More data for this Ligand-Target Pair
Affinity DataIC50: 2.31E+4nMAssay Description:Assays contained 25 pM cathepsin L (RD systems: 952-CY-010), 5 uM LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 20 mM KPO4, p...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Assays contained 25 pM cathepsin L (RD systems: 952-CY-010), 5 uM LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 20 mM KPO4, p...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Assays contained 25 pM thrombin (RD systems: 1473-SE-010), 25 uM BOC—PVR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 μL of 50 mM Tri...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Assays contained 25 pM cathepsin L (RD systems: 952-CY-010), 5 uM LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 20 mM KPO4, p...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Assays contained 25 pM thrombin (RD systems: 1473-SE-010), 25 uM BOC—PVR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 μL of 50 mM Tri...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Assays contained 25 pM thrombin (RD systems: 1473-SE-010), 25 uM BOC—PVR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 μL of 50 mM Tri...More data for this Ligand-Target Pair
