Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 12851
TargetSerine/threonine-protein kinase SIK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733670(1-[2-(1-Hydroxyethyl)-5-[6-[(6-methylpyridazin-3-y...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733670(1-[2-(1-Hydroxyethyl)-5-[6-[(6-methylpyridazin-3-y...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733669(1-[2-(1-Hydroxyethyl)-5-[6-[(6-methylpyridazin-3-y...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733676(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733675(1-[3-Fluoro-2-(1-hydroxyethyl)-5-[6-[(6-methylpyri...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733672(3-[[3-[4-cyano-3-[3-(difluoromethoxy)-5-methyl-pyr...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733673(1-[2-(1-Hydroxyethyl)-5-[6-(6-methylpyridazin-3-yl...)
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733669(1-[2-(1-Hydroxyethyl)-5-[6-[(6-methylpyridazin-3-y...)
Affinity DataIC50: 16nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733675(1-[3-Fluoro-2-(1-hydroxyethyl)-5-[6-[(6-methylpyri...)
Affinity DataIC50: 21nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733671(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Affinity DataIC50: 27nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733676(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Affinity DataIC50: 52nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733673(1-[2-(1-Hydroxyethyl)-5-[6-(6-methylpyridazin-3-yl...)
Affinity DataIC50: 106nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733674(3-[[3-[4-Cyano-3-[3-(difluoromethoxy)-5-methyl-pyr...)
Affinity DataIC50: 152nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733671(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Affinity DataIC50: 207nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733672(3-[[3-[4-cyano-3-[3-(difluoromethoxy)-5-methyl-pyr...)
Affinity DataIC50: 207nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733674(3-[[3-[4-Cyano-3-[3-(difluoromethoxy)-5-methyl-pyr...)
Affinity DataIC50: 366nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733670(1-[2-(1-Hydroxyethyl)-5-[6-[(6-methylpyridazin-3-y...)
Affinity DataIC50: 616nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733669(1-[2-(1-Hydroxyethyl)-5-[6-[(6-methylpyridazin-3-y...)
Affinity DataIC50: 2.80E+3nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733675(1-[3-Fluoro-2-(1-hydroxyethyl)-5-[6-[(6-methylpyri...)
Affinity DataIC50: 6.01E+3nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733673(1-[2-(1-Hydroxyethyl)-5-[6-(6-methylpyridazin-3-yl...)
Affinity DataIC50: 1.46E+4nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733671(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Affinity DataIC50: 1.66E+4nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733672(3-[[3-[4-cyano-3-[3-(difluoromethoxy)-5-methyl-pyr...)
Affinity DataIC50: 1.86E+4nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733676(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Affinity DataIC50: 3.00E+4nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733674(3-[[3-[4-Cyano-3-[3-(difluoromethoxy)-5-methyl-pyr...)
Affinity DataIC50: 3.00E+4nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent